PMID- 2464392
OWN - NLM
STAT- MEDLINE
DCOM- 19890322
LR  - 20061115
IS  - 0007-1285 (Print)
IS  - 0007-1285 (Linking)
VI  - 61
IP  - 732
DP  - 1988 Dec
TI  - Reduction of tumour bed effect after angiogenic stimulation.
PG  - 1168-71
AB  - A new two-tumour system has been developed to examine the effect of an angiogenic 
      stimulus on the tumour bed effect (TBE) in C3H mouse skin treated with 20 Gy X 
      rays. The first tumour was implanted intradermally to stimulate angiogenesis. The 
      Lewis lung carcinoma (3LL) was used for this since it is isogeneic in C57 B1 mice 
      and after initial growth (mean volume 69 mm3), tumours completely regressed 
      within 24 days. The second tumour, the RIF-1 fibrosarcoma (RIF) isogeneic to C3H 
      mice was used to assess stromal function using the TBE assay. After complete 
      regression of the 3LL tumour, RIF cells were implanted into the centre of the 
      stimulated sites and 24 days later the resulting RIF tumours were excised and the 
      TBE measured from the yield of viable RIF cells obtained from each tumour. There 
      was an approximately 10-fold increase in cell yield from tumours implanted into 
      stimulated, pre-irradiated beds compared with those implanted into unstimulated, 
      pre-irradiated beds. This suggests that the angiogenic stimulus provided by the 
      growth of the 3LL tumour led to a substantial restoration of the capacity of the 
      radiation-damaged stroma to support tumour growth. If stromal restoration, as 
      seen during these experiments using artificially induced angiogenesis, was to 
      occur in unstimulated stroma during the normal course of repair and regeneration, 
      this slowly dividing tissue constituent might eventually recover given sufficient 
      time. This raises the possibility that the role of the stroma in late radiation 
      damage might not be as important as was previously thought.
FAU - Penhaligon, M
AU  - Penhaligon M
AD  - Richard Dimbleby Department of Cancer Research, United Medical School, St Thomas 
      Hospital, London.
FAU - Courtenay, V D
AU  - Courtenay VD
FAU - Camplejohn, R S
AU  - Camplejohn RS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Radiol
JT  - The British journal of radiology
JID - 0373125
SB  - IM
MH  - Animals
MH  - Cell Division
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Neoplasm Transplantation
MH  - Neoplasms, Experimental/*pathology
MH  - Neovascularization, Pathologic/*pathology
MH  - Radiation Injuries, Experimental/*pathology
MH  - Skin/*radiation effects
MH  - Skin Neoplasms/*pathology
MH  - Time Factors
EDAT- 1988/12/01 00:00
MHDA- 1988/12/01 00:01
CRDT- 1988/12/01 00:00
PHST- 1988/12/01 00:00 [pubmed]
PHST- 1988/12/01 00:01 [medline]
PHST- 1988/12/01 00:00 [entrez]
AID - 10.1259/0007-1285-61-732-1168 [doi]
PST - ppublish
SO  - Br J Radiol. 1988 Dec;61(732):1168-71. doi: 10.1259/0007-1285-61-732-1168.