PMID- 24645976
OWN - NLM
STAT- MEDLINE
DCOM- 20150109
LR  - 20140404
IS  - 1600-0714 (Electronic)
IS  - 0904-2512 (Linking)
VI  - 43
IP  - 4
DP  - 2014 Apr
TI  - Her2 expression and gene amplification is rarely detectable in patients with oral 
      squamous cell carcinomas.
PG  - 304-8
LID - 10.1111/jop.12173 [doi]
AB  - PURPOSE: Her2 (ErbB2) transforms cells when overexpressed and is an important 
      therapeutic target in breast cancer. Contrary to breast cancer, studies on Her2 
      overexpression and gene amplification in squamous cell carcinomas of the head and 
      neck region described largely different results. This study was undertaken to 
      learn more on the prevalence and clinical significance of HER2 amplification and 
      overexpression in squamous cell carcinomas of the head and neck. MATERIALS AND 
      METHODS: Her2 expression and gene amplification was analyzed by 
      immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) on two 
      tissue microarrays composed of 427 squamous cell carcinomas of the head and neck 
      region and 222 oral squamous cell carcinomas. Results were compared with 
      clinicopathological features. RESULTS: Her2 expression and gene amplification was 
      rarely detectable in squamous cell carcinomas of the head and neck region and 
      unrelated to tumor phenotype or survival of the patients with oral squamous 
      carcinoma. DISCUSSION: Our results demonstrate that Her2 protein and gene 
      amplification was only detectable in a small subset of squamous cell carcinomas 
      of the head and neck region as well as oral squamous cell carcinomas. However, it 
      can be speculated that those few patients with Her2 overexpressing and gene 
      amplificated tumors may possibly benefit from an anti-Her2 therapy.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Hanken, Henning
AU  - Hanken H
AD  - Department of Oral and Maxillofacial Surgery, University Medical Center 
      Hamburg-Eppendorf, Hamburg, Germany.
FAU - Gaudin, Robert
AU  - Gaudin R
FAU - Grobe, Alexander
AU  - Grobe A
FAU - Fraederich, Meike
AU  - Fraederich M
FAU - Eichhorn, Wolfgang
AU  - Eichhorn W
FAU - Smeets, Ralf
AU  - Smeets R
FAU - Simon, Ronald
AU  - Simon R
FAU - Sauter, Guido
AU  - Sauter G
FAU - Grupp, Katharina
AU  - Grupp K
FAU - Izbicki, Jacob R
AU  - Izbicki JR
FAU - Sehner, Susanne
AU  - Sehner S
FAU - Heiland, Max
AU  - Heiland M
FAU - Blessmann, Marco
AU  - Blessmann M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20140320
PL  - Denmark
TA  - J Oral Pathol Med
JT  - Journal of oral pathology & medicine : official publication of the International 
      Association of Oral Pathologists and the American Academy of Oral Pathology
JID - 8911934
RN  - EC 2.7.10.1 (ERBB2 protein, human)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*chemistry/genetics/pathology/secondary
MH  - Female
MH  - Follow-Up Studies
MH  - Gene Amplification/*genetics
MH  - Gene Expression Regulation, Neoplastic/genetics
MH  - Head and Neck Neoplasms/chemistry/genetics/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Lymph Nodes/pathology
MH  - Male
MH  - Middle Aged
MH  - Mouth Floor/chemistry/pathology
MH  - Mouth Neoplasms/*chemistry/genetics/pathology
MH  - Neoplasm Grading
MH  - Neoplasm Recurrence, Local/pathology
MH  - Neoplasm Staging
MH  - Pharyngeal Neoplasms/chemistry/genetics/pathology
MH  - Phenotype
MH  - Receptor, ErbB-2/*analysis/genetics
MH  - Survival Rate
MH  - Tissue Array Analysis/methods
OTO - NOTNLM
OT  - Her2
OT  - fluorescence in situ hybridization
OT  - head and neck squamous cell carcinoma
OT  - immunohistochemistry
OT  - oral squamous cell carcinomas
EDAT- 2014/03/22 06:00
MHDA- 2015/01/13 06:00
CRDT- 2014/03/21 06:00
PHST- 2014/01/30 00:00 [accepted]
PHST- 2014/03/21 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
AID - 10.1111/jop.12173 [doi]
PST - ppublish
SO  - J Oral Pathol Med. 2014 Apr;43(4):304-8. doi: 10.1111/jop.12173. Epub 2014 Mar 
      20.