PMID- 24646139
OWN - NLM
STAT- MEDLINE
DCOM- 20150105
LR  - 20221207
IS  - 1651-2251 (Electronic)
IS  - 0001-6489 (Linking)
VI  - 134
IP  - 6
DP  - 2014 Jun
TI  - Epidermal growth factor receptor mutations in Chinese patients with laryngeal 
      squamous cell carcinoma.
PG  - 631-5
LID - 10.3109/00016489.2013.879741 [doi]
AB  - CONCLUSION: The epidermal growth factor receptor (EGFR) mutation is rare in 
      patients with laryngeal squamous cell carcinoma (LSCC) in China. OBJECTIVE: To 
      determine the incidence of EGFR mutations in patients with LSCC who underwent 
      surgical resection in mainland China. METHODS: xTAG technology was used to detect 
      the EGFR exon 19, exon 20, and exon 21 mutations in 132 patients with LSCC who 
      underwent surgical treatment in our hospital from 2010 to 2013. RESULTS: Of the 
      132 LSCC specimens examined, only 1 specimen was found to be positive for EGFR 
      exon 20 mutation (0.76%). The mutation was p.T790M in exon 20. Two LSCC specimens 
      were positive for EGFR exon 21 mutation (1.52%). The mutation was p.L858R in exon 
      21. None of the samples was found to be positive for EGFR exon 19 mutation.
FAU - Wang, De-Sheng
AU  - Wang DS
AD  - Department of Otolaryngology, Affiliated Union Hospital of Fujian Medical 
      University , Fujian, Fuzhou , China.
FAU - Lai, Hai-Chun
AU  - Lai HC
FAU - Huang, Jian-Min
AU  - Huang JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140319
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/*genetics
MH  - Carcinoma, Squamous Cell/*genetics/pathology/surgery
MH  - China
MH  - Cohort Studies
MH  - ErbB Receptors/*genetics
MH  - Exons/genetics
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Mutation/*genetics
OTO - NOTNLM
OT  - EGFR
OT  - LSCC
OT  - gene mutation
OT  - xTAG technology
EDAT- 2014/03/22 06:00
MHDA- 2015/01/06 06:00
CRDT- 2014/03/21 06:00
PHST- 2014/03/21 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2015/01/06 06:00 [medline]
AID - 10.3109/00016489.2013.879741 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2014 Jun;134(6):631-5. doi: 10.3109/00016489.2013.879741. Epub 
      2014 Mar 19.