PMID- 2464619
OWN - NLM
STAT- MEDLINE
DCOM- 19890316
LR  - 20071114
IS  - 0021-9967 (Print)
IS  - 0021-9967 (Linking)
VI  - 274
IP  - 3
DP  - 1988 Aug 15
TI  - Maturation of rat visual cortex: IV. The generation, migration, morphogenesis, 
      and connectivity of atypically oriented pyramidal neurons.
PG  - 387-405
AB  - The generation, migration, and morphogenesis of atypically oriented pyramidal 
      neurons in the rat visual cortex were examined. In the mature cortex, these 
      neurons were distributed through layers II-VI. Moreover, the atypically oriented 
      pyramidal neurons in a particular layer tended to be oriented in a specific way; 
      atypically oriented pyramidal neurons in layer II, layers III-VIa, and layer VIb 
      were obliquely, radially, and obliquely oriented, respectively. 
      Ultrastructurally, the somata of atypically oriented pyramidal neurons contained 
      large euchromatic ovoid nuclei and cytoplasm that was replete with rough 
      endoplasmic reticulum and Golgi apparatus. These somata formed only symmetric 
      axosomatic synapses. Many atypically oriented pyramidal neurons projected axons 
      into the white matter as demonstrated by a Golgi method and by a retrograde 
      tract-tracing technique; however, some of these pyramidal neurons in layers III-V 
      had axons that ascended to layer I. By using a technique which combined 
      retrograde tract tracing with [3H]thymidine autoradiography, it was determined 
      that most atypically oriented pyramidal neurons in layers V and VIa, layer IV, 
      and layer II were generated on gestational days (GD) 15-17, GD 17-19, and GD 
      20-21, respectively. Atypically oreinted pyramidal neurons were identified during 
      the period from postnatal day 0 (day of birth) to day 30. On day 0, obliquely 
      oriented pyramidal neurons were distributed in the deep cortical plate, i.e., 
      immature layer VI. On day 3, the youngest atypically oriented pyramidal neurons 
      were radially oriented and were located in layer IV. Some obliquely oriented 
      pyramidal neurons were present in layer II on day 6, but the greatest number and 
      the most severely canted pyramidal neurons in layer II were evident on day 9. The 
      orientations of the cell body and the apical dendrite did not change appreciably 
      after migration was complete, except for those in layers V and VI with obliquely 
      oriented cell bodies and radially oriented apical dendrites. The second and third 
      postnatal weeks were marked by substantial morphological differentiation of all 
      pyramidal neurons as noted by the lengthening and branching of dendrites and by 
      the appearance of dendritic spines. By the fourth postnatal week, atypically 
      oriented pyramidal neurons achieved their mature morphology. The generation, 
      migration, and morphogenesis of atypically oriented pyramidal neurons proceed by 
      an inside-to-outside sequence. This development is similar and concurrent with 
      that of typically oriented pyramidal neurons.
FAU - Miller, M W
AU  - Miller MW
AD  - Department of Anatomy, School of Osteopathic Medicine, University of Medicine and 
      Dentistry, Piscataway, New Jersey 08854-5635.
LA  - eng
GR  - AA 06916/AA/NIAAA NIH HHS/United States
GR  - DE07734/DE/NIDCR NIH HHS/United States
GR  - EY 05003/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
RN  - 0 (Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate)
RN  - 0 (Wheat Germ Agglutinins)
RN  - EC 1.11.1.- (Horseradish Peroxidase)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Animals, Newborn
MH  - Axonal Transport
MH  - Golgi Apparatus/ultrastructure
MH  - Horseradish Peroxidase
MH  - Microscopy, Electron
MH  - Morphogenesis
MH  - Neurons/*physiology/ultrastructure
MH  - Pyramidal Tracts/anatomy & histology/*growth & development/physiology
MH  - Rats
MH  - Rats, Inbred Strains/anatomy & histology/*growth & development
MH  - Visual Cortex/anatomy & histology/*growth & development/physiology
MH  - Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
MH  - Wheat Germ Agglutinins
EDAT- 1988/08/15 00:00
MHDA- 1988/08/15 00:01
CRDT- 1988/08/15 00:00
PHST- 1988/08/15 00:00 [pubmed]
PHST- 1988/08/15 00:01 [medline]
PHST- 1988/08/15 00:00 [entrez]
AID - 10.1002/cne.902740308 [doi]
PST - ppublish
SO  - J Comp Neurol. 1988 Aug 15;274(3):387-405. doi: 10.1002/cne.902740308.