PMID- 24646467
OWN - NLM
STAT- MEDLINE
DCOM- 20140512
LR  - 20240324
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 93
IP  - 2
DP  - 2014 Mar
TI  - Henoch-Schonlein purpura in northern Spain: clinical spectrum of the disease in 
      417 patients from a single center.
PG  - 106-113
LID - 10.1097/MD.0000000000000019 [doi]
LID - 106-113
AB  - The severity of clinical features and the outcomes in previous series of patients 
      reported with Henoch-Schonlein purpura (HSP) vary greatly, probably due to 
      selection bias. To establish the actual clinical spectrum of HSP in all age 
      groups using an unselected and wide series of patients diagnosed at a single 
      center, we performed a retrospective review of 417 patients classified as having 
      HSP according to the criteria proposed by Michel et al. Of 417 patients, 240 were 
      male and 177 female, with a median age at the time of disease diagnosis of 7.5 
      years (interquartile range [IQR], 5.3-20.1 yr). Three-quarters of the patients 
      were children or young people aged 20 years or younger (n = 315), and one-quarter 
      were adults (n = 102). The most frequent precipitating events were a previous 
      infection (38%), usually an upper respiratory tract infection, and/or drug intake 
      (18.5%) shortly before the onset of the vasculitis. At disease onset the most 
      common manifestations were skin lesions (55.9%), nephropathy (24%), 
      gastrointestinal involvement (13.7%), joint symptoms (9.1%), and fever (6.2%). 
      Cutaneous involvement occurring in all patients, mainly purpuric skin lesion, was 
      the most common manifestation when the vasculitis was fully established, followed 
      by gastrointestinal (64.5%), joint (63.1%), and renal involvement (41.2%). The 
      main laboratory findings were leukocytosis (36.7%), anemia (8.9%), and increased 
      serum IgA levels (31.7%). The most frequent therapies used were corticosteroids 
      (35%), nonsteroidal antiinflammatory drugs (14%), and cytotoxic agents (5%). 
      After a median follow-up of 12 months (IQR, 2-38 mo), complete recovery was 
      observed in most cases (n = 346; 83.2%), while persistent, usually mild, 
      nephropathy was observed in only 32 (7.7%) cases. Relapses were observed in 
      almost a third of patients (n = 133; 31.9%).In conclusion, although HSP is a 
      typical vasculitis affecting children and young people, it is not uncommon in 
      adults. The prognosis is favorable in most cases, depending largely on renal 
      involvement.
FAU - Calvo-Rio, Vanesa
AU  - Calvo-Rio V
AD  - From Divisions of Rheumatology (VC-R, JL, CM, FO-S, JR-G, EP, MAG-G, RB), 
      Nephrology (LM, MA), Pediatrics (LA, DG-L), Pathology (MCG-V), and Dermatology 
      (HF-L, MAG-L, SA), Hospital Universitario Marques de Valdecilla, IDIVAL, 
      Santander, Spain.
FAU - Loricera, Javier
AU  - Loricera J
FAU - Mata, Cristina
AU  - Mata C
FAU - Martin, Luis
AU  - Martin L
FAU - Ortiz-Sanjuan, Francisco
AU  - Ortiz-Sanjuan F
FAU - Alvarez, Lino
AU  - Alvarez L
FAU - Gonzalez-Vela, M Carmen
AU  - Gonzalez-Vela MC
FAU - Gonzalez-Lamuno, Domingo
AU  - Gonzalez-Lamuno D
FAU - Rueda-Gotor, Javier
AU  - Rueda-Gotor J
FAU - Fernandez-Llaca, Hector
AU  - Fernandez-Llaca H
FAU - Gonzalez-Lopez, Marcos A
AU  - Gonzalez-Lopez MA
FAU - Armesto, Susana
AU  - Armesto S
FAU - Peiro, Enriqueta
AU  - Peiro E
FAU - Arias, Manuel
AU  - Arias M
FAU - Gonzalez-Gay, Miguel A
AU  - Gonzalez-Gay MA
FAU - Blanco, Ricardo
AU  - Blanco R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Adrenal Cortex Hormones)
SB  - IM
MH  - Adolescent
MH  - Adrenal Cortex Hormones
MH  - Age of Onset
MH  - Child
MH  - Diagnosis, Differential
MH  - Female
MH  - Hematologic Tests
MH  - Humans
MH  - IgA Vasculitis/diagnosis/*physiopathology/therapy
MH  - Male
MH  - Retrospective Studies
MH  - Seasons
MH  - Spain
PMC - PMC4616305
COIS- *Drs. Gonzalez-Gay and Blanco share senior authorship. Financial support and 
      conflicts of interest: This study was supported by a grant from "Fondo de 
      Investigaciones Sanitarias" PI12/00193 (Spain). This work was also partially 
      supported by RETICS Programs, RD08/0075 (RIER) and RD12/0009/0013 from "Instituto 
      de Salud Carlos III" (ISCIII) (Spain). The authors have no conflicts of interest 
      to disclose.
EDAT- 2014/03/22 06:00
MHDA- 2014/05/13 06:00
PMCR- 2014/03/04
CRDT- 2014/03/21 06:00
PHST- 2014/03/21 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2014/05/13 06:00 [medline]
PHST- 2014/03/04 00:00 [pmc-release]
AID - 00005792-201403000-00006 [pii]
AID - MD130059 [pii]
AID - 10.1097/MD.0000000000000019 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2014 Mar;93(2):106-113. doi: 10.1097/MD.0000000000000019.