PMID- 24646632
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140324
LR  - 20211021
IS  - 1828-695X (Print)
IS  - 2049-6958 (Electronic)
IS  - 1828-695X (Linking)
VI  - 9
IP  - 1
DP  - 2014 Mar 19
TI  - The association of human leukocyte antigen polymorphisms with disease severity 
      and latency period in patients with silicosis.
PG  - 17
LID - 10.1186/2049-6958-9-17 [doi]
AB  - BACKGROUND: Denim sandblasting may cause silicosis as a result of free 
      crystalline silica inhalation. Its pathogenesis remains unclear, but autoimmunity 
      may play a role in the development of silicosis. The present study aimed to 
      investigate the relationships between human leukocyte antigen (HLA) and the 
      severity and latency period of silicosis. METHODS: 48 silicotic patients in the 
      Eastern part of Turkey were classified according to their latency period and 
      disease severity. The distribution of HLAs according to disease severity and 
      latency period was assessed. RESULTS: A23 (7.5%), B49 (7.5%), and B51 (25%) were 
      more common in the mild group than in the severe group, and B55 (8.9%) and DR4 
      (17.9%) were more common in the severe group than in the mild one. Only B51 was 
      significantly more common in the mild group than in the severe one (25%, n = 10 
      vs. 7.1%, n = 4; p = 0.016). CONCLUSIONS: This study suggests that HLA antigens 
      may play a particular role in the severity of silica-induced lung disease, but 
      there was no association between HLA and progression time of the disease.
FAU - Dogan, Hasan
AU  - Dogan H
AD  - Medical Biology Department, Faculty of Medicine, Ataturk University, Erzurum 
      25240, Turkey. dthdogan@gmail.com.
FAU - Akgun, Metin
AU  - Akgun M
FAU - Araz, Omer
AU  - Araz O
FAU - Ucar, Elif Yilmazel
AU  - Ucar EY
FAU - Yoruk, Ozgur
AU  - Yoruk O
FAU - Diyarbakir, Eda
AU  - Diyarbakir E
FAU - Atis, Omer
AU  - Atis O
FAU - Akdemir, Fatih
AU  - Akdemir F
FAU - Acemoglu, Hamit
AU  - Acemoglu H
FAU - Pirim, Ibrahim
AU  - Pirim I
LA  - eng
PT  - Journal Article
DEP - 20140319
PL  - Italy
TA  - Multidiscip Respir Med
JT  - Multidisciplinary respiratory medicine
JID - 101477642
PMC - PMC3994697
EDAT- 2014/03/22 06:00
MHDA- 2014/03/22 06:01
PMCR- 2014/03/19
CRDT- 2014/03/21 06:00
PHST- 2013/12/30 00:00 [received]
PHST- 2014/03/11 00:00 [accepted]
PHST- 2014/03/21 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2014/03/22 06:01 [medline]
PHST- 2014/03/19 00:00 [pmc-release]
AID - 2049-6958-9-17 [pii]
AID - 10.1186/2049-6958-9-17 [doi]
PST - epublish
SO  - Multidiscip Respir Med. 2014 Mar 19;9(1):17. doi: 10.1186/2049-6958-9-17.