PMID- 24647337
OWN - NLM
STAT- MEDLINE
DCOM- 20150120
LR  - 20190720
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 37
IP  - 6
DP  - 2014
TI  - Effects of curcumin analogues for inhibiting human prostate cancer cells and the 
      growth of human PC-3 prostate xenografts in immunodeficient mice.
PG  - 1029-34
AB  - Four curcumin analogues ((2E,6E)-2,6-bis(thiophen-3-methylene) cyclohexanone 
      (AS), (2E,5E)-2,5-bis(thiophen-3-methylene) cyclopentanone (BS), 
      (3E,5E)-3,5-bis(thiophen-3-methylene)-tetrahydropyran-4-one (ES) and 
      (3E,5E)-3,5-bis(thiophen-3-methylene)-tetrahydrothiopyran-4-one (FS) as shown in 
      Fig. 1) with different linker groups were investigated for their effects in human 
      prostate cancer CWR-22Rv1 and PC-3 cells. Compounds FS and ES had stronger 
      inhibitory effects than curcumin, AS and BS on the growth of cultured CWR-22Rv1 
      and PC-3 cells, as well as on the androgen receptor (AR) and nuclear factor kappa 
      B (NF-kappaB) activity. The strong activities of ES and FS may be correlated with a 
      heteroatom linker. In animal studies, severe combined immunodeficient (SCID) mice 
      were injected subcutaneously (s.c.) with PC-3 cells in Matrigel. After 4 to 6 
      weeks, mice with PC-3 tumors (about 0.6 cm wide and 0.6 cm long) received daily 
      intraperitoneal (i.p.) injections of vehicle, ES and FS (10 microg/g body weight) for 
      31 d. FS had a potent effect in inhibiting the growth and progression of PC-3 
      tumors. Our results indicate that FS may be useful for inhibiting human prostate 
      tumors growth.
FAU - Zhou, Dai-Ying
AU  - Zhou DY
AD  - Guangdong Food and Drug Vocational College.
FAU - Ding, Ning
AU  - Ding N
FAU - Van Doren, Jeremiah
AU  - Van Doren J
FAU - Wei, Xing-Chuan
AU  - Wei XC
FAU - Du, Zhi-Yun
AU  - Du ZY
FAU - Conney, Allan H
AU  - Conney AH
FAU - Zhang, Kun
AU  - Zhang K
FAU - Zheng, Xi
AU  - Zheng X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140319
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (NF-kappa B)
RN  - 0 (Receptors, Androgen)
RN  - 3XMK78S47O (Testosterone)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - Cell Line, Tumor
MH  - Cell Survival/drug effects
MH  - Curcumin/*analogs & derivatives/chemistry/*pharmacology/therapeutic use
MH  - Dose-Response Relationship, Drug
MH  - Gene Expression/drug effects
MH  - Genes, Reporter
MH  - Humans
MH  - Male
MH  - Mice, SCID
MH  - Molecular Structure
MH  - NF-kappa B/genetics/metabolism
MH  - Prostatic Neoplasms/*drug therapy/metabolism/pathology
MH  - Receptors, Androgen/genetics/metabolism
MH  - Structure-Activity Relationship
MH  - Testosterone/pharmacology
MH  - Xenograft Model Antitumor Assays
EDAT- 2014/03/22 06:00
MHDA- 2015/01/21 06:00
CRDT- 2014/03/21 06:00
PHST- 2014/03/21 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2015/01/21 06:00 [medline]
AID - DN/JST.JSTAGE/bpb/b14-00044 [pii]
AID - 10.1248/bpb.b14-00044 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2014;37(6):1029-34. doi: 10.1248/bpb.b14-00044. Epub 2014 Mar 
      19.