PMID- 24647582
OWN - NLM
STAT- MEDLINE
DCOM- 20150119
LR  - 20211021
IS  - 1469-0756 (Electronic)
IS  - 0032-5473 (Print)
IS  - 0032-5473 (Linking)
VI  - 90
IP  - 1063
DP  - 2014 May
TI  - Eosinophilic oesophagitis: clinical presentation and pathogenesis.
PG  - 282-9
LID - 10.1136/postgradmedj-2012-131403 [doi]
AB  - Eosinophilic oesophagitis (EoE) is an inflammatory disorder of the oesophagus 
      which has become increasingly recognised over recent years, although it remains 
      underdiagnosed in many centres. It is characterised histologically by a 
      significant eosinophilic infiltration of the oesophageal mucosa (>15 eosinophils 
      per high powered field), and clinically with features of oesophageal dysfunction 
      such a dysphagia, food impaction, and proton pump inhibitor (PPI) resistant 
      dyspepsia. Fibrosis and oesophageal remodelling may occur and lead to oesophageal 
      strictures. An allergic predisposition is common in the EoE population, which 
      appears to be primarily food antigen driven in children and aeroallergen driven 
      in adults. Evidence suggests that the pathogenesis of EoE is due to a 
      dysregulated immunological response to an environmental allergen, resulting in a 
      T helper type 2 (Th2) inflammatory disease and remodelling of the oesophagus in 
      genetically susceptible individuals. Allergen elimination and anti-inflammatory 
      therapy with corticosteroids are currently the mainstay of treatment; however, an 
      increasing number of studies are now focused on targeting different stages in the 
      disease pathogenesis. A greater understanding of the underlying mechanisms 
      resulting in EoE will allow us to improve the therapeutic options available.
FAU - Bystrom, Jonas
AU  - Bystrom J
AD  - Bone and Joint Research Unit, William Harvey Research Institute, Barts & the 
      London, Queen Mary University of London, , London, UK.
FAU - O'Shea, Nuala R
AU  - O'Shea NR
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140319
PL  - England
TA  - Postgrad Med J
JT  - Postgraduate medical journal
JID - 0234135
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Anti-Inflammatory Agents)
SB  - IM
CIN - doi: 10.1136/postgradmedj-2013-131843
MH  - Adrenal Cortex Hormones/*administration & dosage
MH  - Adult
MH  - Anti-Inflammatory Agents/*administration & dosage
MH  - Constriction, Pathologic/diagnosis/therapy
MH  - Deglutition Disorders/etiology
MH  - Dilatation/methods
MH  - Eosinophilic 
      Esophagitis/complications/*diagnosis/pathology/physiopathology/therapy
MH  - Esophagus/*pathology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Treatment Outcome
PMC - PMC4495666
OTO - NOTNLM
OT  - HISTOPATHOLOGY
OT  - IMMUNOLOGY
OT  - PUBLIC HEALTH
EDAT- 2014/03/22 06:00
MHDA- 2015/01/20 06:00
PMCR- 2015/07/08
CRDT- 2014/03/21 06:00
PHST- 2014/03/21 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2015/01/20 06:00 [medline]
PHST- 2015/07/08 00:00 [pmc-release]
AID - postgradmedj-2012-131403 [pii]
AID - 10.1136/postgradmedj-2012-131403 [doi]
PST - ppublish
SO  - Postgrad Med J. 2014 May;90(1063):282-9. doi: 10.1136/postgradmedj-2012-131403. 
      Epub 2014 Mar 19.