PMID- 24648214
OWN - NLM
STAT- MEDLINE
DCOM- 20141209
LR  - 20140416
IS  - 1098-2299 (Electronic)
IS  - 0272-4391 (Linking)
VI  - 75
IP  - 2
DP  - 2014 Mar
TI  - Low-dose aspirin ameliorated hyperlipidemia, adhesion molecule, and chemokine 
      production induced by high-fat diet in Sprague-Dawley rats.
PG  - 97-106
LID - 10.1002/ddr.21159 [doi]
AB  - In this study the effects of low-dose aspirin (5 mg/kg) on adhesion molecule and 
      chemokine expression in a hyperlipidemic rat model. Six-week-old Sprague-Dawley 
      (SD) rats were assigned to two control groups receiving either a regular diet or 
      high-fat diet (HFD) and a treatment group fed HFD with 5 mg/kg aspirin for a 
      10-week period. Compared with the regular diet control group, the HFD control 
      group had higher body weight, lower levels of high-density lipoprotein, higher 
      concentrations of insulin, triglyceride, total cholesterol, and low-density 
      lipoprotein, but no differences in blood glucose and glycated hemoglobin. The 
      prothrombin time (PT) and activated partial thromboplastin time (aPTT) were 
      clearly shortened in the HFD group. That group also had increased expression of 
      intercellular adhesion molecule-1 (ICAM-1), ICAM-2, ICAM-3, vascular cell 
      adhesion molecule (VCAM), platelet endothelial cell adhesion molecule (PECAM) and 
      P-selectin in platelets and vascular adhesion protein-1 in lymphocyte and in 
      aorta increased expressions of ICAM-1, ICAM-2, ICAM-3, VCAM, PECAM, E-selectin, 
      monocyte chemoattractant protein-1 (MCP-1) and CCR2. The HFD rats also had 
      increased PKCalpha, IkappaB kinase alpha (IKKalpha), p65, mitogen-activated protein kinases 
      (MAPKs) (p38, c-Jun N-terminal kinases 1, extracellular signal-regulated kinase 
      1/2), and their phosphorylated forms. Low-dose aspirin improved HFD-induced 
      hyperinsulinemia and hyperlipidemia, recovered PT and aPTT, inhibited 
      upregulation of adhesion molecules and chemokines and reduced expression of PKCalpha, 
      IKKalpha, p65, and MAPKs. Low-dose aspirin ameliorates HFD-induced hyperlipidemia and 
      hyperinsulinemia, and prevents HFD-induced expression of adhesion molecules and 
      chemokine formation.
CI  - (c) 2013 Wiley Periodicals, Inc.
FAU - Lin, Hui-Li
AU  - Lin HL
AD  - Department of Food Science and Nutrition, Meiho University, Pingtung, Taiwan.
FAU - Yen, Hsueh-Wei
AU  - Yen HW
FAU - Hsieh, Su-Ling
AU  - Hsieh SL
FAU - An, Li-Mei
AU  - An LM
FAU - Shen, Kuo-Ping
AU  - Shen KP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131223
PL  - United States
TA  - Drug Dev Res
JT  - Drug development research
JID - 8204468
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Chemokines)
RN  - 0 (Lipids)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/*therapeutic use
MH  - Aorta, Thoracic/drug effects/metabolism
MH  - Aspirin/administration & dosage/*therapeutic use
MH  - Atherosclerosis/etiology/immunology/metabolism/prevention & control
MH  - Blood Platelets/immunology/metabolism
MH  - Body Weight/drug effects
MH  - Cell Adhesion Molecules/biosynthesis/*blood
MH  - Chemokines/*blood/immunology
MH  - Diet, High-Fat/*adverse effects
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Hyperlipidemias/blood/complications/immunology/*prevention & control
MH  - Lipids/blood
MH  - Lymphocytes/immunology/metabolism
MH  - Male
MH  - Rats, Sprague-Dawley
MH  - Weight Gain/drug effects
OTO - NOTNLM
OT  - adhesion molecules and chemokines
OT  - aspirin
OT  - hyperlipidemia
EDAT- 2014/03/22 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/03/21 06:00
PHST- 2013/10/04 00:00 [received]
PHST- 2013/11/06 00:00 [accepted]
PHST- 2014/03/21 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1002/ddr.21159 [doi]
PST - ppublish
SO  - Drug Dev Res. 2014 Mar;75(2):97-106. doi: 10.1002/ddr.21159. Epub 2013 Dec 23.