PMID- 24648685
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140320
LR  - 20211021
IS  - 1013-9087 (Print)
IS  - 2005-3894 (Electronic)
IS  - 1013-9087 (Linking)
VI  - 26
IP  - 1
DP  - 2014 Feb
TI  - Effects of adapalene-benzoyl peroxide combination gel in treatment or maintenance 
      therapy of moderate or severe acne vulgaris: a meta-analysis.
PG  - 43-52
LID - 10.5021/ad.2014.26.1.43 [doi]
AB  - BACKGROUND: An antibiotic-free, fixed-dose combination gel with adapalene (A) 
      0.1% and benzoyl peroxide (BPO) 2.5% has been developed for treatment of acne 
      vulgaris. OBJECTIVE: To compare the clinical outcomes of A-BPO combination gel 
      with vehicle gel for treatment or maintenance therapy of patients with acne 
      vulgaris. METHODS: An electronic search of the database PubMed (1966 to September 
      2012), Embase (1984 to September 2012), and Cochrane Controlled Trials Register 
      (CENTRAL; 3rd Quarter, 2012) was undertaken to identify relevant studies. Main 
      clinical outcomes were success rate, treatment-related adverse events (AEs), AEs 
      leading to discontinuation, satisfaction with the effectiveness, and overall 
      satisfaction. RESULTS: Six studies were finally included in this meta-analysis. 
      The A-BPO group yielded better clinical outcomes regarding the success rate 
      (p<0.00001), satisfaction with the effectiveness of treatment (p=0.005), and 
      overall satisfaction (p=0.005) compared to the vehicle group. The incidence of 
      treatment-related AEs in the A-BPO group was comparable with that of vehicle 
      group (p=0.09), while the A-BPO group was associated with a slightly increase in 
      the incidence of AEs leading to discontinuation when compared with the vehicle 
      group (p=0.02). CONCLUSION: A-BPO combination gel yields better clinical outcomes 
      including success rate, satisfaction with the effectiveness, and overall 
      satisfaction compared to vehicle gel, despite an increased incidence of AEs 
      leading to discontinuation. The A-BPO combination agent most likely contributes 
      to the treatment of moderate acne vulgaris rather than severe acne vulgaris, but 
      it may be useful in maintenance therapy of patients with severe acne vulgaris.
FAU - Zhou, Rongying
AU  - Zhou R
AD  - Department of Dermatology, West China Hospital, Sichuan University, Chengdu, 
      China.
FAU - Jiang, Xian
AU  - Jiang X
AD  - Department of Dermatology, West China Hospital, Sichuan University, Chengdu, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20140217
PL  - Korea (South)
TA  - Ann Dermatol
JT  - Annals of dermatology
JID - 8916577
PMC - PMC3956794
OTO - NOTNLM
OT  - Acne vulgaris
OT  - Adapalene
OT  - Benzoyl peroxide
OT  - Meta-analysis
EDAT- 2014/03/22 06:00
MHDA- 2014/03/22 06:01
PMCR- 2014/02/01
CRDT- 2014/03/21 06:00
PHST- 2012/09/12 00:00 [received]
PHST- 2013/01/04 00:00 [revised]
PHST- 2013/01/05 00:00 [accepted]
PHST- 2014/03/21 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2014/03/22 06:01 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - 10.5021/ad.2014.26.1.43 [doi]
PST - ppublish
SO  - Ann Dermatol. 2014 Feb;26(1):43-52. doi: 10.5021/ad.2014.26.1.43. Epub 2014 Feb 
      17.