PMID- 24648723
OWN - NLM
STAT- MEDLINE
DCOM- 20140929
LR  - 20221207
IS  - 1178-1998 (Electronic)
IS  - 1176-9092 (Print)
IS  - 1176-9092 (Linking)
VI  - 9
DP  - 2014
TI  - Effects of fluoxetine on brain-derived neurotrophic factor serum concentration 
      and cognition in patients with vascular dementia.
PG  - 411-8
LID - 10.2147/CIA.S58830 [doi]
AB  - BACKGROUND: Selective serotonin reuptake inhibitors improve cognition in patients 
      with stroke and increase the expression of brain-derived neurotrophic factor 
      (BDNF) in the rat hippocampus. However, the effects of selective serotonin 
      reuptake inhibitors on cognition and serum BDNF levels in patients with vascular 
      dementia are largely unknown. We performed an open-label study to investigate the 
      effects of fluoxetine, a selective serotonin reuptake inhibitor, on cognition and 
      serum BDNF levels in patients with vascular dementia. METHODS: Fifty patients 
      with vascular dementia were randomly allocated to receive fluoxetine (20 mg/day; 
      n=25) or no fluoxetine (control group; n=25) for 12 weeks. Both groups received 
      secondary prevention of stroke. Serum BDNF level, Mini-Mental State Examination 
      (MMSE) score, Ten-Point Clock Drawing score, and Digit Span Test and Verbal 
      Fluency Test scores were measured at baseline and at week 12 in the both groups. 
      RESULTS: The baseline serum BDNF level correlated significantly with the MMSE 
      score. MMSE score, Ten-Point Clock Drawing score, and serum BDNF level increased 
      significantly in the fluoxetine group but not in the control group. The increase 
      in serum BDNF level correlated with the increase in MMSE score in the fluoxetine 
      group. CONCLUSION: Fluoxetine may potentially improve cognition in patients with 
      vascular dementia and requires further investigation. BDNF may play an important 
      role in cognitive recovery.
FAU - Liu, Xuan
AU  - Liu X
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, Wuhan, People's 
      Republic of China ; Department of Neurology, Xiangyang Central Hospital, Medical 
      College, Hubei University of Arts and Science, Xiangyang, Hubei, People's 
      Republic of China.
FAU - Zhang, Junjian
AU  - Zhang J
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, Wuhan, People's 
      Republic of China.
FAU - Sun, Dong
AU  - Sun D
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, Wuhan, People's 
      Republic of China.
FAU - Fan, Yuanteng
AU  - Fan Y
AD  - Department of Neurology, Zhongnan Hospital, Wuhan University, Wuhan, People's 
      Republic of China.
FAU - Zhou, Hongbin
AU  - Zhou H
AD  - Department of Neurology, Xiangyang Central Hospital, Medical College, Hubei 
      University of Arts and Science, Xiangyang, Hubei, People's Republic of China.
FAU - Fu, Binfang
AU  - Fu B
AD  - Department of Neurology, Xiangyang Central Hospital, Medical College, Hubei 
      University of Arts and Science, Xiangyang, Hubei, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20140310
PL  - New Zealand
TA  - Clin Interv Aging
JT  - Clinical interventions in aging
JID - 101273480
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 01K63SUP8D (Fluoxetine)
SB  - IM
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cognition/*drug effects
MH  - Dementia, Vascular/blood/*drug therapy
MH  - Female
MH  - Fluoxetine/*therapeutic use
MH  - Humans
MH  - Male
MH  - Neuropsychological Tests
MH  - Selective Serotonin Reuptake Inhibitors/*therapeutic use
PMC - PMC3956624
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - cognition
OT  - fluoxetine
OT  - improvement
OT  - neuroplasticity
OT  - vascular dementia
EDAT- 2014/03/22 06:00
MHDA- 2014/09/30 06:00
PMCR- 2014/03/10
CRDT- 2014/03/21 06:00
PHST- 2014/03/21 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2014/09/30 06:00 [medline]
PHST- 2014/03/10 00:00 [pmc-release]
AID - cia-9-411 [pii]
AID - 10.2147/CIA.S58830 [doi]
PST - epublish
SO  - Clin Interv Aging. 2014 Mar 10;9:411-8. doi: 10.2147/CIA.S58830. eCollection 
      2014.