PMID- 24648914 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20211021 IS - 2049-9434 (Print) IS - 2049-9442 (Electronic) IS - 2049-9434 (Linking) VI - 1 IP - 2 DP - 2013 Mar TI - The neuroprotective roles of BDNF in hypoxic ischemic brain injury. PG - 167-176 AB - Hypoxia-ischemia (H/I) brain injury results in various degrees of damage to the body, and the immature brain is particularly fragile to oxygen deprivation. Hypothermia and erythropoietin (EPO) have long been known to be neuroprotective in ischemic brain injury. Brain-derived neurotrophic factor (BDNF) has recently been recognized as a potent modulator capable of regulating a wide repertoire of neuronal functions. This review was based on studies concerning the involvement of BDNF in the protection of H/I brain injury following a search in PubMed between 1995 and December, 2011. We initially examined the background of BDNF, and then focused on its neuroprotective mechanisms against ischemic brain injury, including its involvement in promoting neural regeneration/cognition/memory rehabilitation, angiogenesis within ischemic penumbra and the inhibition of the inflammatory process, neurotoxicity, epilepsy and apoptosis. We also provided a literature overview of experimental studies, discussing the safety and the potential clinical application of BDNF as a neuroprotective agent in the ischemic brain injury. FAU - Chen, Ai AU - Chen A AD - Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China ; FAU - Xiong, Li-Jing AU - Xiong LJ AD - Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China ; FAU - Tong, Yu AU - Tong Y AD - Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, Chengdu, Sichuan 610041, P.R. China ; ; Laboratory of Early Developmental and Injuries, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China ; FAU - Mao, Meng AU - Mao M AD - Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China ; LA - eng PT - Review DEP - 20121214 PL - England TA - Biomed Rep JT - Biomedical reports JID - 101613227 PMC - PMC3956206 OTO - NOTNLM OT - brain injury OT - brain-derived neurotrophic factor OT - hypoxic OT - ischemia EDAT- 2014/03/22 06:00 MHDA- 2014/03/22 06:01 PMCR- 2012/12/14 CRDT- 2014/03/21 06:00 PHST- 2012/09/01 00:00 [received] PHST- 2012/10/16 00:00 [accepted] PHST- 2014/03/21 06:00 [entrez] PHST- 2014/03/22 06:00 [pubmed] PHST- 2014/03/22 06:01 [medline] PHST- 2012/12/14 00:00 [pmc-release] AID - br-01-02-0167 [pii] AID - 10.3892/br.2012.48 [doi] PST - ppublish SO - Biomed Rep. 2013 Mar;1(2):167-176. doi: 10.3892/br.2012.48. Epub 2012 Dec 14.