PMID- 24648922
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2049-9434 (Print)
IS  - 2049-9442 (Electronic)
IS  - 2049-9434 (Linking)
VI  - 1
IP  - 2
DP  - 2013 Mar
TI  - Synovial TGF-beta1 and MMP-3 levels and their correlation with the progression of 
      temporomandibular joint osteoarthritis combined with disc displacement: A 
      preliminary study.
PG  - 218-222
AB  - Osteoarthritis (OA) is a slow progressing degenerative disease that affects the 
      joints, including the temporomandibular joint. In the present study, transforming 
      growth factor-beta1 (TGF-beta1) and matrix metalloproteinase 3 (MMP-3) in synovial 
      fluid (SF) were examined in detecting cartilage synthesis and degradation in 
      progression of temporomandibular joint osteoarthritis (TMJ OA) combined with disc 
      displacement (DD) diseases. SF was obtained from 16 patients with TMJ OA combined 
      with DD and 10 normal volunteers. TGF-beta1 and MMP-3 levels were measured by 
      enzyme-linked immunosorbent assay. In addition, TMJ OA combined with DD was 
      classified into three stages based on radiographic signs on the preoperative 
      tomograms and surgical findings at operation, and different treatment options 
      were administered according to the stages. SF from TMJs with TMJ OA combined with 
      DD showed higher levels of TGF-beta1 and MMP-3 compared with the asymptomatic 
      control TMJs. With the progression of TMJ OA combined with DD, TGF-beta1 levels in 
      SF were lower, while MMP-3 levels in SF were significantly higher. In conclusion, 
      these data suggest that MMP-3 is not only involved in the pathological 
      destruction process of TMJ OA combined with DD initially, but also has a positive 
      correlation with the degree of pathological changes. Furthermore, a significant 
      increase of TGF-beta1 levels was found in the SF that were able to counteract the 
      deleterious effects of MMP-3 at the early stage of TMJ OA combined DD, providing 
      the scientific basis on repositioning displaced disc as early as possible for 
      these patients.
FAU - Jiang, Qian
AU  - Jiang Q
AD  - Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai 
      JiaoTong University, School of Medicine, Shanghai Key Laboratory of Stomatology, 
      Shanghai 200011, P.R. China.
FAU - Qiu, Ya-Ting
AU  - Qiu YT
AD  - Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai 
      JiaoTong University, School of Medicine, Shanghai Key Laboratory of Stomatology, 
      Shanghai 200011, P.R. China.
FAU - Chen, Min-Jie
AU  - Chen MJ
AD  - Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai 
      JiaoTong University, School of Medicine, Shanghai Key Laboratory of Stomatology, 
      Shanghai 200011, P.R. China.
FAU - Zhang, Zhi-Yuan
AU  - Zhang ZY
AD  - Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai 
      JiaoTong University, School of Medicine, Shanghai Key Laboratory of Stomatology, 
      Shanghai 200011, P.R. China.
FAU - Yang, Chi
AU  - Yang C
AD  - Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai 
      JiaoTong University, School of Medicine, Shanghai Key Laboratory of Stomatology, 
      Shanghai 200011, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20121126
PL  - England
TA  - Biomed Rep
JT  - Biomedical reports
JID - 101613227
PMC - PMC3956210
OTO - NOTNLM
OT  - matrix metalloproteinase 3
OT  - opening disc displacement
OT  - osteoarthritis
OT  - synovial fluid
OT  - temporomandibular joint
OT  - transforming growth factor-beta1
EDAT- 2014/03/22 06:00
MHDA- 2014/03/22 06:01
PMCR- 2012/11/26
CRDT- 2014/03/21 06:00
PHST- 2012/08/09 00:00 [received]
PHST- 2012/10/12 00:00 [accepted]
PHST- 2014/03/21 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2014/03/22 06:01 [medline]
PHST- 2012/11/26 00:00 [pmc-release]
AID - br-01-02-0218 [pii]
AID - 10.3892/br.2012.41 [doi]
PST - ppublish
SO  - Biomed Rep. 2013 Mar;1(2):218-222. doi: 10.3892/br.2012.41. Epub 2012 Nov 26.