PMID- 24648949
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2049-9434 (Print)
IS  - 2049-9442 (Electronic)
IS  - 2049-9434 (Linking)
VI  - 1
IP  - 3
DP  - 2013 May
TI  - Effects of aging and uninephrectomy on renal changes in Tsukuba hypertensive 
      mice.
PG  - 359-364
AB  - Renal dysfunction is accelerated by various factors such as hypertension, aging 
      and diabetes. Glomerular hyper-filtration, considered one of the major risk 
      factors leading to diabetic nephropathy, is often encountered in diabetic 
      patients. However, the interrelationship of these risk factors during the course 
      and development of renal dysfunction has not been fully elucidated. In this 
      study, the effects of aging and uninephrectomy (UNx)-induced hyperfiltration on 
      renal changes were investigated in Tsukuba hypertensive mice (THM) carrying both 
      human renin and angiotensinogen genes. In THM, the urinary albumin/creatinine 
      (Alb/Cr) ratio was elevated with age without a concomitant increase in the plasma 
      Cr concentration. Moreover, the urinary neutrophil gelatinase-associated 
      lipocalin/Cr (NGAL/Cr) ratio, the renal monocyte chemoattractant protein-1 
      (MCP-1) mRNA expression and the renal collagen type I alpha 2 (COL1A2) mRNA 
      expression were also increased with age. Age-related albuminuria in THM is likely 
      caused by renal tubular damage, enhanced inflammatory response and 
      tubulointerstitial fibrosis. Furthermore, following UNx, the urinary Alb/Cr ratio 
      and the plasma Cr concentration were increased in THM. The urinary NGAL/Cr ratio 
      and the renal MCP-1 and COL1A2 mRNA expression were not affected by UNx. These 
      results suggested that UNx-induced albuminuria in THM was caused by glomerular 
      dysfunction, rather than renal tubular injury. In conclusion, this study 
      demonstrated for the first time the effects of aging and UNx on renal changes in 
      THM. These findings strongly reinforce the significance of applying a diversity 
      of therapeutic approaches to the management of renal dysfunction.
FAU - Inui, Yosuke
AU  - Inui Y
AD  - Pharmacology Research Laboratories II, Mitsubishi Tanabe Pharma Corporation, 
      Toda, Saitama 335-8505; ; Life Science Center, Tsukuba Advanced Research 
      Alliance, Graduate School of Life and Environmental Sciences, University of 
      Tsukuba, Tsukuba, Ibaraki 305-8577, Japan.
FAU - Mochida, Hideki
AU  - Mochida H
AD  - Pharmacology Research Laboratories II, Mitsubishi Tanabe Pharma Corporation, 
      Toda, Saitama 335-8505;
FAU - Yamairi, Fumiko
AU  - Yamairi F
AD  - Advanced Medical Research Laboratory, Mitsubishi Tanabe Pharma Corporation, Toda, 
      Saitama 335-8505;
FAU - Okada, Miyoko
AU  - Okada M
AD  - Safety Research Laboratory, Mitsubishi Tanabe Pharma Corporation, Kisarazu, Chiba 
      292-0818;
FAU - Ishida, Junji
AU  - Ishida J
AD  - Life Science Center, Tsukuba Advanced Research Alliance, Graduate School of Life 
      and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8577, 
      Japan.
FAU - Fukamizu, Akiyoshi
AU  - Fukamizu A
AD  - Life Science Center, Tsukuba Advanced Research Alliance, Graduate School of Life 
      and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8577, 
      Japan.
FAU - Arakawa, Kenji
AU  - Arakawa K
AD  - Pharmacology Research Laboratories II, Mitsubishi Tanabe Pharma Corporation, 
      Toda, Saitama 335-8505;
LA  - eng
PT  - Journal Article
DEP - 20130307
PL  - England
TA  - Biomed Rep
JT  - Biomedical reports
JID - 101613227
PMC - PMC3917043
OTO - NOTNLM
OT  - Tsukuba hypertensive mice
OT  - aging
OT  - albuminuria
OT  - glomerular hyperfiltration
OT  - hypertension
OT  - renal disease
EDAT- 2014/03/22 06:00
MHDA- 2014/03/22 06:01
PMCR- 2013/03/07
CRDT- 2014/03/21 06:00
PHST- 2012/12/28 00:00 [received]
PHST- 2013/02/26 00:00 [accepted]
PHST- 2014/03/21 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2014/03/22 06:01 [medline]
PHST- 2013/03/07 00:00 [pmc-release]
AID - br-01-03-0359 [pii]
AID - 10.3892/br.2013.74 [doi]
PST - ppublish
SO  - Biomed Rep. 2013 May;1(3):359-364. doi: 10.3892/br.2013.74. Epub 2013 Mar 7.