PMID- 24649021
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2049-9434 (Print)
IS  - 2049-9442 (Electronic)
IS  - 2049-9434 (Linking)
VI  - 1
IP  - 5
DP  - 2013 Sep
TI  - MicroRNA expression and its detection in human supraglottic laryngeal squamous 
      cell carcinoma.
PG  - 743-746
AB  - Laryngeal squamous cell carcinoma (LSCC) is one of the most common head and neck 
      malignancies with a poor prognosis. The aim of this study was to detect the 
      expression of microRNAs (miRNAs) in supraglottic LSCC and attached normal mucosa 
      using microarray assay, and explore the role of miRNAs in supraglottic LSCC. 
      Fresh-frozen samples of five supraglottic LSCC and attached normal mucosa were 
      obtained, and their various endogenous miRNAs were screened by microarray. miRNAs 
      of interest were confirmed by quantitative real-time polymerase chain reaction 
      (qRT-PCR) in 48 supraglottic LSCC tumors and 10 normal mucosa tissues. In total, 
      38 miRNAs were differentially expressed in supraglottic LSCC, with 22 miRNAs 
      being upregulated and 16 downregulated. Of the six miRNAs selected for qRT-PCR, 
      miR-375, miR-139-3P, miR-1290 and miR-106b were differentially expressed in 
      supraglottic LSCC with and without lymphatic metastasis.
FAU - Sun, Xin
AU  - Sun X
AD  - Department of Otorhinolaryngology, Shengjing Hospital, China Medical University, 
      Shenyang, Liaoning 110004, P.R. China.
FAU - Song, Yan
AU  - Song Y
AD  - Department of Otorhinolaryngology, Shengjing Hospital, China Medical University, 
      Shenyang, Liaoning 110004, P.R. China.
FAU - Tai, Xuhui
AU  - Tai X
AD  - Department of Otorhinolaryngology, Chinese PLA 463 Hospital, Shenyang, Liaoning 
      110042, P.R. China.
FAU - Liu, Bin
AU  - Liu B
AD  - Department of Otorhinolaryngology, Shengjing Hospital, China Medical University, 
      Shenyang, Liaoning 110004, P.R. China.
FAU - Ji, Wenyue
AU  - Ji W
AD  - Department of Otorhinolaryngology, Shengjing Hospital, China Medical University, 
      Shenyang, Liaoning 110004, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20130722
PL  - England
TA  - Biomed Rep
JT  - Biomedical reports
JID - 101613227
PMC - PMC3917082
OTO - NOTNLM
OT  - lymphatic metastasis
OT  - microarray
OT  - quantitative real-time polymerase chain reaction
OT  - supraglottic laryngeal carcinoma
EDAT- 2014/03/22 06:00
MHDA- 2014/03/22 06:01
PMCR- 2013/07/22
CRDT- 2014/03/21 06:00
PHST- 2013/05/14 00:00 [received]
PHST- 2013/07/10 00:00 [accepted]
PHST- 2014/03/21 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2014/03/22 06:01 [medline]
PHST- 2013/07/22 00:00 [pmc-release]
AID - br-01-05-0743 [pii]
AID - 10.3892/br.2013.143 [doi]
PST - ppublish
SO  - Biomed Rep. 2013 Sep;1(5):743-746. doi: 10.3892/br.2013.143. Epub 2013 Jul 22.