PMID- 24649023
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2049-9434 (Print)
IS  - 2049-9442 (Electronic)
IS  - 2049-9434 (Linking)
VI  - 1
IP  - 5
DP  - 2013 Sep
TI  - Association of human leukocyte antigen gene polymorphism and mesangial 
      proliferative glomerulonephritis in a large population-based study.
PG  - 751-756
AB  - The aim of the present study was to investigate the association of human 
      leukocyte antigen (HLA) gene polymorphism and clinical phenotypes of patients 
      with mesangial proliferative glomerulonephritis (MsPGN). The genotyping of HLA-A, 
      HLA-B and HLA-DRB1 alleles was detected in 1,536 consecutive MsPGN patients 
      during the previous five years and 2,027 age- and gender-matched healthy 
      individuals by using the polymerase chain reaction-sequence-specific primers 
      method. The clinical and pathological data of the patients were collected and the 
      genotype frequencies (GF) and odds ratio (OR) were analyzed. The allele 
      frequencies of HLA-A*23, A*25, B*15, B*40, B*53 and DRB1*18 were significantly 
      higher in MsPGN patients than in the controls (P<0.05). These alleles were 
      considered as the suspected susceptibility genes (SSG) for MsPGN. Of note, 
      results of the follow-up survey study demonstrated poorer prognosis of patients 
      with SSG than those without SSG. On the other hand, the frequencies of A*32, 
      A*33, B*50, B*58, B*60, B*71, DRB1*16 were lower in MsPGN patients than in the 
      controls (P<0.05). However, the alleles A*20, A*22, A*35, A*36, A*38, B*21, B*73 
      and B*78 were not expressed in MsPGN patients. HLA gene polymorphism is 
      associated with hereditary susceptibility to MsPGN. Therefore, there might be 
      corresponding susceptibility and protective genes associated with MsPGN.
FAU - Zhao, Jing-Jie
AU  - Zhao JJ
AD  - Clinical Molecular Biology Laboratory, The Second Hospital of Shandong 
      University, Jinan, Shandong 250033, P.R. China.
FAU - Wang, Xi-Bing
AU  - Wang XB
AD  - Department of Gynaecology and Obstetrics, Maternal and Child Health Care Service 
      Center of Zaozhuang, Shandong 277102, P.R. China.
FAU - Luan, Yun
AU  - Luan Y
AD  - Central Laboratory, The Second Hospital of Shandong University, Jinan, Shandong 
      250033, P.R. China.
FAU - Liu, Jun-Li
AU  - Liu JL
AD  - Clinical Molecular Biology Laboratory, The Second Hospital of Shandong 
      University, Jinan, Shandong 250033, P.R. China.
FAU - Liu, Ling
AU  - Liu L
AD  - Clinical Molecular Biology Laboratory, The Second Hospital of Shandong 
      University, Jinan, Shandong 250033, P.R. China.
FAU - Jia, Hong-Ying
AU  - Jia HY
AD  - Department of Scientific Research, The Second Hospital of Shandong University, 
      Jinan, Shandong 250033, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20130722
PL  - England
TA  - Biomed Rep
JT  - Biomedical reports
JID - 101613227
PMC - PMC3917055
OTO - NOTNLM
OT  - gene frequency
OT  - glomerulonephritis
OT  - human leukocyte antigen
OT  - mesangial proliferative glomerulonephritis
EDAT- 2014/03/22 06:00
MHDA- 2014/03/22 06:01
PMCR- 2013/07/22
CRDT- 2014/03/21 06:00
PHST- 2013/06/17 00:00 [received]
PHST- 2013/07/16 00:00 [accepted]
PHST- 2014/03/21 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2014/03/22 06:01 [medline]
PHST- 2013/07/22 00:00 [pmc-release]
AID - br-01-05-0751 [pii]
AID - 10.3892/br.2013.152 [doi]
PST - ppublish
SO  - Biomed Rep. 2013 Sep;1(5):751-756. doi: 10.3892/br.2013.152. Epub 2013 Jul 22.