PMID- 24649269
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 2049-9450 (Print)
IS  - 2049-9469 (Electronic)
IS  - 2049-9450 (Linking)
VI  - 1
IP  - 5
DP  - 2013 Sep
TI  - Clinical characteristics of acute promyelocytic leukemia manifesting as early 
      death.
PG  - 908-910
AB  - Acute promyelocytic leukemia (APL) is currently considered to be a highly curable 
      disease. However, early death (ED) remains a major cause of treatment failure in 
      APL. The purpose of this study was to retrospectively review the morphological, 
      immunophenotypic and molecular characteristics of 26 patients with APL resulting 
      in ED. It was observed that elevated white blood cell (WBC) counts, lower 
      fibrinogen concentrations, morphological variant M3v, CD34(+) and the short form 
      (S- or bcr3 form) of the PML-RARalpha transcript were significantly associated with 
      ED, mainly due to cerebral hemorrhage. Admission on weekends or holidays without 
      immediate diagnosis or prompt administration of treatment for APL resulted in 
      intracranial bleeding and was the major cause of ED. Therefore, it is recommended 
      that APL and coagulopathy management treatments are promptly initiated only upon 
      morphological and clinical suspicion of APL on admission, in order to reduce the 
      risk of severe bleeding and lower the rate of ED.
FAU - He, Bai
AU  - He B
AD  - Department of Hematology, The First People's Hospital of Changzhou (Third 
      Affiliated Hospital of Suzhou University), Changzhou, Jiangsu 213003, P.R. China.
FAU - Hu, Shaoyan
AU  - Hu S
AD  - Department of Hematology and Oncology, Children's Hospital of Suzhou University, 
      Suzhou, Jiangsu 215003, P.R. China.
FAU - Qiu, Guoqiang
AU  - Qiu G
AD  - Department of Hematology, The First People's Hospital of Changzhou (Third 
      Affiliated Hospital of Suzhou University), Changzhou, Jiangsu 213003, P.R. China.
FAU - Gu, Weiying
AU  - Gu W
AD  - Department of Hematology, The First People's Hospital of Changzhou (Third 
      Affiliated Hospital of Suzhou University), Changzhou, Jiangsu 213003, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20130723
PL  - England
TA  - Mol Clin Oncol
JT  - Molecular and clinical oncology
JID - 101613422
PMC - PMC3915273
OTO - NOTNLM
OT  - acute promyelocytic leukemia
OT  - early death
OT  - immunophenotype
EDAT- 2014/03/22 06:00
MHDA- 2014/03/22 06:01
PMCR- 2013/07/23
CRDT- 2014/03/21 06:00
PHST- 2013/01/08 00:00 [received]
PHST- 2013/06/25 00:00 [accepted]
PHST- 2014/03/21 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2014/03/22 06:01 [medline]
PHST- 2013/07/23 00:00 [pmc-release]
AID - mco-01-05-0908 [pii]
AID - 10.3892/mco.2013.155 [doi]
PST - ppublish
SO  - Mol Clin Oncol. 2013 Sep;1(5):908-910. doi: 10.3892/mco.2013.155. Epub 2013 Jul 
      23.