PMID- 24649307
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2049-9450 (Print)
IS  - 2049-9469 (Electronic)
IS  - 2049-9450 (Linking)
VI  - 2
IP  - 1
DP  - 2014 Jan
TI  - Downregulation of expression of transporters associated with antigen processing 1 
      and 2 and human leukocyte antigen I and its effect on immunity in nasopharyngeal 
      carcinoma patients.
PG  - 51-58
AB  - The human leukocyte antigen (HLA)-I and antigen-processing machinery (APM) are 
      crucial in the anti-cancer immune response. The aim of this study was to assess 
      the clinical significance of the APM components [transporters associated with 
      antigen processing (TAP)-1 and -2 and HLA-I] in nasopharyngeal carcinoma (NPC). A 
      total of 58 NPC specimens and 20 healthy specimens used as control were evaluated 
      by semiquantitative immunohistochemistry for three APM components (TAP-1, TAP-2 
      and HLA-I). The expression of the APM components in NPC was downregulated. CD4(+) 
      and CD8(+) T cells were measured by flow cytometry and IL-10 was measured by 
      ELISA. The number of CD8(+) T cells and the expression of IL-10 were higher and 
      the number of CD4(+) T cells was lower in NPC, compared to the controls. The 
      number of CD8(+) T cells and the expression of IL-10 were negatively correlated 
      with TAP-1, TAP-2 and HLA-I expression. The clinical phase, lymph node 
      metastasis, distant metastasis, pathological type, TAP-1 expression, TAP-2 
      expression and HLA-I expression were identified as prognostic factors by the 
      Kaplan-Meier analysis. A multivariate analysis using a Cox regression model 
      indicated that distant metastasis and the downregulation of HLA-I expression were 
      independent unfavorable prognostic factors. In conclusion, the lower expression 
      of HLA-I induced immunosuppression in NPC patients and was associated with a poor 
      prognosis.
FAU - Ren, Yan-Xin
AU  - Ren YX
AD  - Head and Neck Tumor Research Center, The Third Affiliated Hospital of Kunming 
      Medical University, Kunming, Yunnan 650118;
FAU - Yang, Jie
AU  - Yang J
AD  - Head and Neck Tumor Research Center, The Third Affiliated Hospital of Kunming 
      Medical University, Kunming, Yunnan 650118;
FAU - Zhang, Li-Juan
AU  - Zhang LJ
AD  - Departments of Pathology, The Third Affiliated Hospital of Kunming Medical 
      University, Kunming, Yunnan 650118;
FAU - Sun, Rui-Mei
AU  - Sun RM
AD  - Head and Neck Tumor Research Center, The Third Affiliated Hospital of Kunming 
      Medical University, Kunming, Yunnan 650118;
FAU - Zhao, Liu-Fang
AU  - Zhao LF
AD  - Head and Neck Tumor Research Center, The Third Affiliated Hospital of Kunming 
      Medical University, Kunming, Yunnan 650118;
FAU - Zhang, Ming
AU  - Zhang M
AD  - Radiotherapy, The Third Affiliated Hospital of Kunming Medical University, 
      Kunming, Yunnan 650118;
FAU - Chen, Yun
AU  - Chen Y
AD  - Departments of Pathology, The Third Affiliated Hospital of Kunming Medical 
      University, Kunming, Yunnan 650118;
FAU - Ma, Jing
AU  - Ma J
AD  - Department of Otolaryngology, Kunming Children's Hospital, Kunming, Yunnan 
      650034;
FAU - Qiao, Kun
AU  - Qiao K
AD  - Head and Neck Tumor Research Center, The Third Affiliated Hospital of Kunming 
      Medical University, Kunming, Yunnan 650118;
FAU - Sun, Qiang-Ming
AU  - Sun QM
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences, The Third 
      Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650118, P.R. 
      China.
FAU - Long, Hai-Ting
AU  - Long HT
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences, The Third 
      Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650118, P.R. 
      China.
FAU - Huang, Yun-Chao
AU  - Huang YC
AD  - Department of Cardiothoracic Surgery, The Third Affiliated Hospital of Kunming 
      Medical University, Kunming, Yunnan 650118, P.R. China.
FAU - Li, Xiao-Jiang
AU  - Li XJ
AD  - Head and Neck Tumor Research Center, The Third Affiliated Hospital of Kunming 
      Medical University, Kunming, Yunnan 650118;
LA  - eng
PT  - Journal Article
DEP - 20130926
PL  - England
TA  - Mol Clin Oncol
JT  - Molecular and clinical oncology
JID - 101613422
PMC - PMC3916213
OTO - NOTNLM
OT  - human leucocyte antigen I
OT  - nasopharyngeal neoplasms
OT  - transporter associated with antigen processing 1
OT  - transporter associated with antigen processing 2
EDAT- 2014/03/22 06:00
MHDA- 2014/03/22 06:01
PMCR- 2013/09/26
CRDT- 2014/03/21 06:00
PHST- 2013/04/10 00:00 [received]
PHST- 2013/07/31 00:00 [accepted]
PHST- 2014/03/21 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2014/03/22 06:01 [medline]
PHST- 2013/09/26 00:00 [pmc-release]
AID - mco-02-01-0051 [pii]
AID - 10.3892/mco.2013.194 [doi]
PST - ppublish
SO  - Mol Clin Oncol. 2014 Jan;2(1):51-58. doi: 10.3892/mco.2013.194. Epub 2013 Sep 26.