PMID- 24649471
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140320
LR  - 20211021
IS  - 2233-6249 (Print)
IS  - 2233-6257 (Electronic)
IS  - 2233-6249 (Linking)
VI  - 3
IP  - 1
DP  - 2013 Jun
TI  - Cefepime- Induced Non-Convulsive Status Epilepticus (NCSE).
PG  - 39-41
LID - 10.14581/jer.13008 [doi]
AB  - Cefepime is a fourth-generation B-lactam cephalosporin, commonly used in 
      immunosuppressed patients. Neurotoxicity, which present as nonconvulsive status 
      epilepticus (NCSE), has been reported previously especially in adult patients 
      with impaired renal function. We present a case of cefepime induced NCSE after 
      recovering from acute renal failure. A 71-year-old woman was hospitalized for 
      right lower lobe lobectomy after diagnosis of lung cancer. Although she had 
      successful lobectomy, she underwent several post operative complication including 
      operation site bleeding, acute renal failure, acute respiratory distress 
      syndrome, and atypical pneumonia. Her renal failure was prerenal type after 
      massive operation site bleeding, and continuous renal replacement therapy (CRRT) 
      were started for renal replacement treatment. After 5 days of renal replacement 
      therapy, her serum creatinine level was much improved from 2.7 mg/dL to 1.33 
      mg/dL. Cefepime renal dose were started, when atypical pneumonia became resistant 
      to imipenem and vancomycin. After 5th day of cefepime use, the patient became 
      stupor and developed one episode of brief generalized myoclonic seizure. Her 
      electroencephalograph (EEG) revealed 2-3 Hz generalized sharp and with impression 
      of NCSE, she was started on anti-epileptic treatment. Clinical symptoms improved 
      3 days after discontinuation of cefepime. She was than diagnosed with cefepime 
      induced non convulsive status epilepticus. Anti-epileptic treatments were than 
      discontinued uneventfully. Awareness of the potential neurotoxic clinical 
      manifestations of various antibiotics and high degree of vigilance in critically 
      ill patients is essential in identifying a potentially serious though reversible 
      complication of antibiotic therapy.
FAU - Kim, Ahro
AU  - Kim A
AD  - Department of Neurology, Ilsan Paik Hospital, Inje University College of 
      Medicine.
FAU - Kim, Ji-Eun
AU  - Kim JE
AD  - Department of Neurology, Ilsan Paik Hospital, Inje University College of 
      Medicine.
FAU - Paek, Young-Min
AU  - Paek YM
AD  - Department of Neurology, Ilsan Paik Hospital, Inje University College of 
      Medicine.
FAU - Hong, Keun-Sik
AU  - Hong KS
AD  - Department of Neurology, Ilsan Paik Hospital, Inje University College of 
      Medicine.
FAU - Cho, Young-Jin
AU  - Cho YJ
AD  - Department of Neurology, Ilsan Paik Hospital, Inje University College of 
      Medicine.
FAU - Cho, Joong-Yang
AU  - Cho JY
AD  - Department of Neurology, Ilsan Paik Hospital, Inje University College of 
      Medicine.
FAU - Park, Hee-Kyung
AU  - Park HK
AD  - Department of Neurology, Ilsan Paik Hospital, Inje University College of 
      Medicine.
FAU - Koo, Hyeon-Kyoung
AU  - Koo HK
AD  - Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of 
      Medicine, Ilsan, Korea.
FAU - Song, Pamela
AU  - Song P
AD  - Department of Neurology, Ilsan Paik Hospital, Inje University College of 
      Medicine.
LA  - eng
PT  - Case Reports
DEP - 20130630
PL  - Korea (South)
TA  - J Epilepsy Res
JT  - Journal of epilepsy research
JID - 101577886
PMC - PMC3957313
OTO - NOTNLM
OT  - Cefepime
OT  - NCSE
OT  - Non-convulsive status epilepticus
EDAT- 2014/03/22 06:00
MHDA- 2014/03/22 06:01
PMCR- 2013/06/30
CRDT- 2014/03/21 06:00
PHST- 2013/05/30 00:00 [received]
PHST- 2013/06/21 00:00 [accepted]
PHST- 2014/03/21 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2014/03/22 06:01 [medline]
PHST- 2013/06/30 00:00 [pmc-release]
AID - er-3-1-39-8 [pii]
AID - 10.14581/jer.13008 [doi]
PST - epublish
SO  - J Epilepsy Res. 2013 Jun 30;3(1):39-41. doi: 10.14581/jer.13008. eCollection 2013 
      Jun.