PMID- 24649901 OWN - NLM STAT- MEDLINE DCOM- 20141201 LR - 20221207 IS - 1399-0039 (Electronic) IS - 0001-2815 (Linking) VI - 83 IP - 5 DP - 2014 May TI - Genetic variants of 17q21 are associated with childhood-onset asthma and related phenotypes in a northeastern Han Chinese population: a case-control study. PG - 330-6 LID - 10.1111/tan.12342 [doi] AB - A genome-wide association study (GWAS) suggested that variants on chromosome 17q21 were associated with childhood-onset asthma in white populations. Two replication studies had been conducted in southern Han Chinese population in 2009 and 2012. However, these two Chinese replication results were inconsistent. To further confirm the role of 17q21 common variants, an association study of 17q21 single nucleotide polymorphisms (SNPs) with the risk of childhood-onset asthma was performed in a Han population from northeastern China. In this study, rs3894194, rs12603332 and rs11650680 were genotyped in 435 asthmatic children and 601 healthy controls by using a SNaPshot method. Our data showed that the allelic frequency of rs12603332 and rs11650680 showed significant differences between asthmatic cases and healthy controls, with an odds ratio (OR) of 1.36 [95% confidence interval (CI) 1.12-1.65, P=0.002] and an OR of 1.36 (95% CI 1.07-1.74, P=0.01). Genotype distribution analysis also showed the significant associations of the above two loci with childhood asthma under dominant, recessive and additive model (dominant OR=1.57, 95% CI 1.04-2.36, P=0.032; recessive OR=1.41, 95% CI 1.09-1.83, P=0.009; additive OR=1.97, 95% CI 1.24-3.14, P=0.004; recessive OR=1.50, 95% CI 1.13-1.98, P=0.005). Besides, linear regression analysis showed that rs3894194 and rs12603332 were also significantly associated with asthma phenotypes such as log10 -transformed immunoglobulin E (IgE) level (IU/ml) and log10 -transformed eosinophil percentage (dominant, P=0.04; additive, P=0.01; recessive, P=0.04; recessive, P=0.03; additive, P=0.02). Collectively, our findings suggest that orosomucoid 1-like 3 (ORMDL3) locus on chromosome 17q21 is a risk factor for childhood-onset asthma in northeastern Han Chinese population. Further studies will be needed to elucidate the pathogenesis that ORMDL3 locus predisposes to childhood-onset asthma. CI - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. FAU - Yu, X AU - Yu X AD - Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, P. R. China; Department of Allergy, Harbin Children Hospital, Harbin, P. R. China. FAU - Yu, C AU - Yu C FAU - Ren, Z AU - Ren Z FAU - Deng, Y AU - Deng Y FAU - Song, J AU - Song J FAU - Zhang, H AU - Zhang H FAU - Zhou, H AU - Zhou H LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140321 PL - England TA - Tissue Antigens JT - Tissue antigens JID - 0331072 RN - 0 (Membrane Proteins) RN - 0 (ORMDL3 protein, human) RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Age of Onset MH - Alleles MH - Asian People MH - Asthma/ethnology/*genetics/immunology MH - Case-Control Studies MH - Child MH - Child, Preschool MH - *Chromosomes, Human, Pair 17 MH - Female MH - Gene Frequency MH - Genetic Loci MH - *Genetic Predisposition to Disease MH - Genome-Wide Association Study MH - Humans MH - Immunoglobulin E/*genetics/immunology MH - Male MH - Membrane Proteins/*genetics/immunology MH - Models, Genetic MH - Phenotype MH - Polymorphism, Single Nucleotide MH - Risk Factors OTO - NOTNLM OT - Han Chinese population OT - ORMDL3 locus OT - childhood-onset asthma OT - common variants OT - single nucleotide polymorphism EDAT- 2014/03/22 06:00 MHDA- 2014/12/15 06:00 CRDT- 2014/03/22 06:00 PHST- 2013/09/02 00:00 [received] PHST- 2014/02/01 00:00 [revised] PHST- 2014/02/23 00:00 [accepted] PHST- 2014/03/22 06:00 [entrez] PHST- 2014/03/22 06:00 [pubmed] PHST- 2014/12/15 06:00 [medline] AID - 10.1111/tan.12342 [doi] PST - ppublish SO - Tissue Antigens. 2014 May;83(5):330-6. doi: 10.1111/tan.12342. Epub 2014 Mar 21.