PMID- 24650234
OWN - NLM
STAT- MEDLINE
DCOM- 20160815
LR  - 20181202
IS  - 1462-2920 (Electronic)
IS  - 1462-2912 (Linking)
VI  - 17
IP  - 12
DP  - 2015 Dec
TI  - Biodegradation of endocrine-disrupting compounds by ligninolytic fungi: 
      mechanisms involved in the degradation.
PG  - 4822-34
LID - 10.1111/1462-2920.12460 [doi]
AB  - Without any doubt, endocrine-disrupting compounds (EDCs) represent an 
      environmental risk for wildlife and human beings. Endocrine-disrupting effects 
      were found for many chemicals in products for personal use, industrial compounds 
      and even in classical persistent organic pollutants (POPs). In order to 
      understand the fate of EDCs in the environment, it is highly important to 
      identify and to clarify the biodegradation mechanisms that can lead to their 
      decomposition. Ligninolytic fungi (LF) are interesting microorganisms that are 
      capable of participating in a variety of versatile decomposition mechanisms. The 
      microorganisms represent a useful model group and, moreover, LF or their enzymes 
      can be actively used for decontamination. Potential optimization of the 
      decontamination process provides another important reason why it is necessary for 
      understanding the mechanisms of EDC transformation. This minireview summarizes 
      current knowledge about the LF biodegradation mechanisms of the most important 
      micropollutants (xenoestrogens), including nonylphenols, bisphenol A and 
      17alpha-ethinylestradiol and polychlorinated biphenyls as POPs with 
      endocrine-disrupting potency. Generally, LF exhibit the ability to either 
      polymerize the target pollutants or to substantially decompose the original 
      structure using ligninolytic enzymes and cytochrome P-450. Moreover, most of the 
      transformation processes are accompanied by reduction of the endocrine-disrupting 
      activity or ecotoxicity.
CI  - (c) 2014 Society for Applied Microbiology and John Wiley & Sons Ltd.
FAU - Cajthaml, Tomas
AU  - Cajthaml T
AD  - Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, 
      Czech Republic.
AD  - Institute for Environmental Studies, Faculty of Science, Charles University in 
      Prague, Prague, Czech Republic.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140418
PL  - England
TA  - Environ Microbiol
JT  - Environmental microbiology
JID - 100883692
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Estrogens, Non-Steroidal)
RN  - 0 (Phenols)
RN  - 79F6A2ILP5 (nonylphenol)
RN  - 9005-53-2 (Lignin)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Benzhydryl Compounds/metabolism
MH  - *Biodegradation, Environmental
MH  - Endocrine Disruptors/*metabolism/toxicity
MH  - Environmental Pollutants/*metabolism/toxicity
MH  - Estrogens, Non-Steroidal/*metabolism/toxicity
MH  - Fungi/*metabolism
MH  - Humans
MH  - Lignin/metabolism
MH  - Phenols/metabolism
MH  - Polychlorinated Biphenyls/metabolism
EDAT- 2014/03/22 06:00
MHDA- 2016/08/16 06:00
CRDT- 2014/03/22 06:00
PHST- 2013/11/22 00:00 [received]
PHST- 2014/03/16 00:00 [accepted]
PHST- 2014/03/22 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2016/08/16 06:00 [medline]
AID - 10.1111/1462-2920.12460 [doi]
PST - ppublish
SO  - Environ Microbiol. 2015 Dec;17(12):4822-34. doi: 10.1111/1462-2920.12460. Epub 
      2014 Apr 18.