PMID- 24650575
OWN - NLM
STAT- MEDLINE
DCOM- 20150414
LR  - 20211021
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Print)
IS  - 1461-1457 (Linking)
VI  - 17
IP  - 8
DP  - 2014 Aug
TI  - Methamphetamine self-administration attenuates hippocampal serotonergic deficits: 
      role of brain-derived neurotrophic factor.
PG  - 1315-20
LID - 10.1017/S1461145714000327 [doi]
AB  - Preclinical studies suggest that prior treatment with escalating doses of 
      methamphetamine (METH) attenuates the persistent deficits in hippocampal 
      serotonin (5-hydroxytryptamine; 5HT) transporter (SERT) function resulting from a 
      subsequent 'binge' METH exposure. Previous work also demonstrates that 
      brain-derived neurotrophic factor (BDNF) exposure increases SERT function. The 
      current study investigated changes in hippocampal BDNF protein and SERT function 
      in rats exposed to saline or METH self-administration prior to a binge exposure 
      to METH or saline. Results revealed that METH self-administration increased 
      hippocampal mature BDNF (mBDNF) immunoreactivity compared to saline-treated rats 
      as assessed 24 h after the start of the last session. Further, mBDNF 
      immunoreactivity was increased and SERT function was not altered in rats that 
      self-administered METH prior to the binge METH exposure as assessed 24 h after 
      the binge exposure. These results suggest that prior exposure to contingent METH 
      increases hippocampal mBDNF, and this may contribute to attenuated deficits in 
      SERT function.
FAU - McFadden, Lisa M
AU  - McFadden LM
AD  - Department of Pharmacology and Toxicology,University of Utah,Salt Lake City, UT 
      84112,USA.
FAU - Vieira-Brock, Paula L
AU  - Vieira-Brock PL
AD  - Department of Pharmacology and Toxicology,University of Utah,Salt Lake City, UT 
      84112,USA.
FAU - Hanson, Glen R
AU  - Hanson GR
AD  - Department of Pharmacology and Toxicology,University of Utah,Salt Lake City, UT 
      84112,USA.
FAU - Fleckenstein, Annette E
AU  - Fleckenstein AE
AD  - Department of Pharmacology and Toxicology,University of Utah,Salt Lake City, UT 
      84112,USA.
LA  - eng
GR  - R01 DA011389/DA/NIDA NIH HHS/United States
GR  - K05 DA000378/DA/NIDA NIH HHS/United States
GR  - P01 DA013367/DA/NIDA NIH HHS/United States
GR  - DA033097/DA/NIDA NIH HHS/United States
GR  - DA019447/DA/NIDA NIH HHS/United States
GR  - K02 DA019447/DA/NIDA NIH HHS/United States
GR  - R01 DA031883/DA/NIDA NIH HHS/United States
GR  - DA013367/DA/NIDA NIH HHS/United States
GR  - DA011389/DA/NIDA NIH HHS/United States
GR  - DA 031883/DA/NIDA NIH HHS/United States
GR  - DA000378/DA/NIDA NIH HHS/United States
GR  - F32 DA033097/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20140320
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (Sert1 protein, rat)
RN  - 10028-17-8 (Tritium)
RN  - 333DO1RDJY (Serotonin)
RN  - 44RAL3456C (Methamphetamine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Hippocampus/diagnostic imaging/*drug effects/*metabolism
MH  - Male
MH  - Methamphetamine/*administration & dosage/*pharmacology
MH  - RNA-Binding Proteins/metabolism
MH  - Radionuclide Imaging
MH  - Rats
MH  - Self Administration
MH  - Serotonin/metabolism
MH  - Synaptosomes/drug effects/metabolism
MH  - Tritium
PMC - PMC4074226
MID - NIHMS567398
EDAT- 2014/03/22 06:00
MHDA- 2015/04/15 06:00
PMCR- 2015/08/01
CRDT- 2014/03/22 06:00
PHST- 2014/03/22 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2015/04/15 06:00 [medline]
PHST- 2015/08/01 00:00 [pmc-release]
AID - S1461145714000327 [pii]
AID - 10.1017/S1461145714000327 [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2014 Aug;17(8):1315-20. doi: 
      10.1017/S1461145714000327. Epub 2014 Mar 20.