PMID- 24650578
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140408
LR  - 20211022
IS  - 1560-8115 (Print)
IS  - 2008-2231 (Electronic)
IS  - 1560-8115 (Linking)
VI  - 22
IP  - 1
DP  - 2014 Mar 20
TI  - Quantification of verbascoside in medicinal species of Phlomis and their genetic 
      relationships.
PG  - 32
LID - 10.1186/2008-2231-22-32 [doi]
AB  - BACKGROUND: The genus Phlomis (Lamiaceae) is introduced by its valuable medicinal 
      species, of which 17 species are growing wildly and ten of them are exclusively 
      endemic of Iran. The main phytochemical characteristic of this genus is presence 
      of iridoid glycosides including ipolamide, auroside, lamiide and also 
      phenylethanoids such as verbascoside (acetoside) found in Lamiales order.Due to 
      the broad range of biological and pharmacological activities of verbascoside and 
      lack of any report on quantification of this compound within Iranian species of 
      Phlomis, we conducted a research to achieve two main goals, finding a genetic 
      biodiversity by RAPD (Randomly Amplified Polymorphic DNA), as well as detecting 
      and quantifying verbascoside in nine species of Phlomis growing wildly in Iran. 
      RESULTS: The results showed that various samples of P.olivieri possess different 
      genetic distances from each other. Also, various species of P.olivieri display 
      close relationships to P.anisodonta and P. persica. Phytoanalysis of Phlomis 
      species by means of TLC scanner using verbascoside as a phytochemical marker 
      showed that the highest concentration of verbascoside was found in P. anisodonta, 
      however, P. bruguieri and P. olivieri (from Mazandaran) were in the second and 
      third places. Interestingly, the lowest concentration of verbascoside was 
      detected in P. olivieri (from Azerbayjan), exhibiting the effect of various 
      growing areas and conditions on the measured levels of this compound. 
      CONCLUSIONS: verbascoside can be found in various species of Iranian Phlomis, of 
      which P. anisodonta, P. bruguieri and P. olivieri might be the best choices. In 
      addition, although the concentration of verbascoside in these plants may be 
      affected by the growing areas and conditions, there are a good agreement between 
      genetic relations and verbascoside levels.
FAU - Sarkhail, Parisa
AU  - Sarkhail P
FAU - Nikan, Marjan
AU  - Nikan M
FAU - Sarkheil, Pantea
AU  - Sarkheil P
FAU - Gohari, Ahmad R
AU  - Gohari AR
FAU - Ajani, Yousef
AU  - Ajani Y
FAU - Hosseini, Rohollah
AU  - Hosseini R
FAU - Hadjiakhoondi, Abbass
AU  - Hadjiakhoondi A
FAU - Saeidnia, Soodabeh
AU  - Saeidnia S
AD  - Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of 
      Medical Sciences, Tehran, Iran. saeidnia_s@tums.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20140320
PL  - Switzerland
TA  - Daru
JT  - Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
JID - 101125969
PMC - PMC3998186
EDAT- 2014/03/22 06:00
MHDA- 2014/03/22 06:01
PMCR- 2014/03/20
CRDT- 2014/03/22 06:00
PHST- 2014/01/04 00:00 [received]
PHST- 2014/03/17 00:00 [accepted]
PHST- 2014/03/22 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2014/03/22 06:01 [medline]
PHST- 2014/03/20 00:00 [pmc-release]
AID - 2008-2231-22-32 [pii]
AID - 10.1186/2008-2231-22-32 [doi]
PST - epublish
SO  - Daru. 2014 Mar 20;22(1):32. doi: 10.1186/2008-2231-22-32.