PMID- 24651157
OWN - NLM
STAT- MEDLINE
DCOM- 20141219
LR  - 20140425
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 5
IP  - 5
DP  - 2014 May
TI  - Antidepressant-like effects of Perilla frutescens seed oil during a forced 
      swimming test.
PG  - 990-6
LID - 10.1039/c3fo60717h [doi]
AB  - Unipolar depressive disorder may become one of the major leading causes of 
      disease burden by 2030 according to the World Health Organization (WHO). Thus, 
      the discovery of antidepressive foods is attractive and could have considerable 
      impacts worldwide. We investigated the antidepressant-like effects of Perilla 
      frutescens seed oil on adult male rats subjected to a forced swimming test (FST). 
      Forty Sprague-Dawley rats were housed and fed various diets, including soybean 
      oil-rich, eicosapentaenoic acid (EPA)-rich, and P. frutescens seed oil-rich diets 
      for 6 weeks. After the dietary intervention, animals were tested using an FST and 
      were sacrificed after the test. We analyzed the fatty acid profiles of red blood 
      cells (RBCs) and the brain prefrontal cortex (PFC). Levels of brain-derived 
      neurotrophic factor (BDNF), serotonin, and dopamine in the PFC were also 
      determined. After the FST, the imipramine, EPA-rich, and P. frutescens seed 
      oil-rich groups showed significant shorter immobility time and longer struggling 
      time than the control group (p < 0.05). Levels of BDNF in the P. frutescens seed 
      oil-rich group and levels of serotonin in the EPA-rich group were significantly 
      (p < 0.05) higher than those of the control group. Moreover, the BDNF 
      concentration in the PFC was significantly positively correlated with the 
      struggling time. However, there were no significant differences in dopamine 
      levels between the intervention groups and the control group. In conclusion, a P. 
      frutescens seed oil-rich diet exhibited antidepressant-like properties through 
      modulation of fatty acid profiles and BDNF expression in the brain during an FST.
FAU - Lee, Hsiu-Chuan
AU  - Lee HC
AD  - School of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Xing 
      Street, Taipei 110, Taiwan. sihuang@tmu.edu.tw.
FAU - Ko, Hsiang-Kai
AU  - Ko HK
FAU - Huang, Brian E T-G
AU  - Huang BE
FAU - Chu, Yan-Hwa
AU  - Chu YH
FAU - Huang, Shih-Yi
AU  - Huang SY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Plant Oils)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Depressive Disorder/*diet therapy/metabolism
MH  - Humans
MH  - Male
MH  - Perilla frutescens/*chemistry/metabolism
MH  - Plant Oils/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Seeds/chemistry/metabolism
MH  - Swimming
EDAT- 2014/03/22 06:00
MHDA- 2014/12/20 06:00
CRDT- 2014/03/22 06:00
PHST- 2014/03/22 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2014/12/20 06:00 [medline]
AID - 10.1039/c3fo60717h [doi]
PST - ppublish
SO  - Food Funct. 2014 May;5(5):990-6. doi: 10.1039/c3fo60717h.