PMID- 24652744
OWN - NLM
STAT- MEDLINE
DCOM- 20140623
LR  - 20140411
IS  - 1521-4141 (Electronic)
IS  - 0014-2980 (Linking)
VI  - 44
IP  - 4
DP  - 2014 Apr
TI  - Regulation of the tolerogenic function of steady-state DCs.
PG  - 927-33
LID - 10.1002/eji.201343862 [doi]
AB  - Dendritic cells (DCs) are master regulators of T-cell responses. After sensing 
      pathogen-derived molecular patterns (PAMPs), or signals of inflammation and 
      cellular stress, DCs differentiate into potent activators of naive CD4(+) and 
      CD8(+) T cells through a process that is termed DC maturation. By contrast, DCs 
      induce and maintain peripheral T-cell tolerance in the steady state, that is in 
      the absence of overt infection or inflammation. However, the immunological steady 
      state is not devoid of DC-activating stimuli, such as commensal microorganisms, 
      subclinical infections, or basal levels of proinflammatory mediators. In the 
      presence of these activating stimuli, DC maturation must be calibrated to ensure 
      self-tolerance yet allow for adequate T-cell responses to infections. Here, we 
      review the factors that are known to control DC maturation in the steady state 
      and discuss their effect on the tolerogenic function of steady-state DCs.
CI  - (c) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Probst, Hans Christian
AU  - Probst HC
AD  - Institute for Immunology, University Medical Center of the Johannes Gutenberg 
      University Mainz, Mainz, Germany; Research Center for Immunology (FZI), Johannes 
      Gutenberg University Mainz, Mainz, Germany.
FAU - Muth, Sabine
AU  - Muth S
FAU - Schild, Hansjorg
AU  - Schild H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140320
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
SB  - IM
MH  - Antigen Presentation/*immunology
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Cell Differentiation/*immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immune Tolerance/immunology
MH  - Models, Immunological
MH  - Signal Transduction/immunology
MH  - T-Lymphocytes, Regulatory/immunology
OTO - NOTNLM
OT  - DC maturation
OT  - Dendritic cells
OT  - Peripheral T-cell tolerance
OT  - Steady-state DCs
EDAT- 2014/03/22 06:00
MHDA- 2014/06/24 06:00
CRDT- 2014/03/22 06:00
PHST- 2013/07/02 00:00 [received]
PHST- 2013/12/13 00:00 [revised]
PHST- 2014/02/11 00:00 [accepted]
PHST- 2014/03/22 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2014/06/24 06:00 [medline]
AID - 10.1002/eji.201343862 [doi]
PST - ppublish
SO  - Eur J Immunol. 2014 Apr;44(4):927-33. doi: 10.1002/eji.201343862. Epub 2014 Mar 
      20.