PMID- 24653686
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140421
LR  - 20220309
IS  - 1662-5153 (Print)
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 8
DP  - 2014
TI  - Contributions of the paraventricular thalamic nucleus in the regulation of 
      stress, motivation, and mood.
PG  - 73
LID - 10.3389/fnbeh.2014.00073 [doi]
LID - 73
AB  - The purpose of this review is to describe how the function and connections of the 
      paraventricular thalamic nucleus (Pa) may play a role in the regulation of stress 
      and negative emotional behavior. Located in the dorsal midline thalamus, the Pa 
      is heavily innervated by serotonin, norepinephrine, dopamine (DA), 
      corticotropin-releasing hormone, and orexins (ORX), and is the only thalamic 
      nucleus connected to the group of structures comprising the amygdala, bed nucleus 
      of the stria terminalis (BNST), nucleus accumbens (NAcc), and 
      infralimbic/subgenual anterior cingulate cortex (sgACC). These neurotransmitter 
      systems and structures are involved in regulating motivation and mood, and 
      display abnormal functioning in several psychiatric disorders including anxiety, 
      substance use, and major depressive disorders (MDD). Furthermore, rodent studies 
      show that the Pa is consistently and potently activated following a variety of 
      stressors and has a unique role in regulating responses to chronic stressors. 
      These observations provide a compelling rationale for investigating the Pa in the 
      link between stress and negative emotional behavior, and for including the Pa in 
      the neural pathways of stress-related psychiatric disorders.
FAU - Hsu, David T
AU  - Hsu DT
AD  - Department of Psychiatry and the Molecular and Behavioral Neuroscience Institute, 
      University of Michigan Ann Arbor, MI, USA.
FAU - Kirouac, Gilbert J
AU  - Kirouac GJ
AD  - Departments of Oral Biology and Psychiatry, Faculties of Dentistry and Medicine, 
      University of Manitoba Winnipeg, MB, Canada.
FAU - Zubieta, Jon-Kar
AU  - Zubieta JK
AD  - Department of Psychiatry and the Molecular and Behavioral Neuroscience Institute, 
      University of Michigan Ann Arbor, MI, USA.
FAU - Bhatnagar, Seema
AU  - Bhatnagar S
AD  - Department of Anesthesiology, Children's Hospital of Philadelphia, University of 
      Pennsylvania Perelman School of Medicine Philadelphia, PA, USA.
LA  - eng
GR  - K01 MH085035/MH/NIMH NIH HHS/United States
GR  - R01 DA016423/DA/NIDA NIH HHS/United States
GR  - UL1 RR024986/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20140311
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC3949320
OTO - NOTNLM
OT  - addiction
OT  - anxiety
OT  - depression
OT  - orexin
OT  - paraventricular
OT  - stress
OT  - subgenual
OT  - thalamus
EDAT- 2014/03/22 06:00
MHDA- 2014/03/22 06:01
PMCR- 2014/01/01
CRDT- 2014/03/22 06:00
PHST- 2014/01/16 00:00 [received]
PHST- 2014/02/20 00:00 [accepted]
PHST- 2014/03/22 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2014/03/22 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fnbeh.2014.00073 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2014 Mar 11;8:73. doi: 10.3389/fnbeh.2014.00073. 
      eCollection 2014.