PMID- 24653759
OWN - NLM
STAT- MEDLINE
DCOM- 20141114
LR  - 20211021
IS  - 1844-3117 (Electronic)
IS  - 1844-122X (Print)
IS  - 1844-122X (Linking)
VI  - 7
IP  - 1
DP  - 2014 Mar 15
TI  - Correlation between macular changes and the peripapillary nerve fiber layer in 
      primary open angle glaucoma.
PG  - 55-9
AB  - Glaucoma is a leading cause of blindness and the early diagnosis is crucial for 
      treatment and follow-up in the progression of the disease. OBJECTIVE: To evaluate 
      the changes in mean macular thickness and volume and compare them with the mean 
      thickness of the peripapillary nerve fiber layer in primary open angle glaucoma, 
      using Time Domain (TD) optical coherence tomography ( OCT). METHOD: The 
      examinations were conducted on 275 eyes of 138 patients, as it follows: 203 eyes 
      of 102 patients diagnosed with primary open angle glaucoma in various stages of 
      evolution, representing the study group, and 72 normal eyes from 36 patients, 
      representing the control group. The study was conducted from March 2010 to 
      December 2012. All the patients gave their consent, in accordance with the 
      Helsinki Declaration. The study group showed a decrease in mean macular thickness 
      and volume, as well as mean thickness of the peripapillary nerve fiber layer 
      (RNFL) compared to the control group. According to the OCT measurements, the 
      results of the study have shown that the decrease of the mean thickness of the 
      RNFL is a better differentiator between glaucomatous and normal eyes compared to 
      the decrease of the mean macular thickness and volume.
FAU - Manasia, D
AU  - Manasia D
AD  - "Titu Maiorescu" University of Medicine Bucharest.
FAU - Voinea, L
AU  - Voinea L
AD  - "Carol Davila" University of Medicine and Pharmacy, Bucharest.
FAU - Vasinca, I D
AU  - Vasinca ID
AD  - "Titu Maiorescu" University of Medicine Bucharest.
FAU - Alexandrescu, C
AU  - Alexandrescu C
AD  - "Carol Davila" University of Medicine and Pharmacy, Bucharest.
LA  - eng
PT  - Journal Article
DEP - 20140325
PL  - Romania
TA  - J Med Life
JT  - Journal of medicine and life
JID - 101477617
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Glaucoma, Open-Angle/*diagnosis/*pathology
MH  - Humans
MH  - Macula Lutea/*pathology
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Retinal Neurons/*pathology
MH  - Tomography, Optical Coherence
PMC - PMC3956098
OTO - NOTNLM
OT  - RNFL
OT  - glaucoma
OT  - macula
OT  - optical coherence tomography
EDAT- 2014/03/22 06:00
MHDA- 2014/11/15 06:00
PMCR- 2014/05/15
CRDT- 2014/03/22 06:00
PHST- 2013/09/28 00:00 [received]
PHST- 2014/01/07 00:00 [accepted]
PHST- 2014/03/22 06:00 [entrez]
PHST- 2014/03/22 06:00 [pubmed]
PHST- 2014/11/15 06:00 [medline]
PHST- 2014/05/15 00:00 [pmc-release]
AID - JMedLife-07-55 [pii]
PST - ppublish
SO  - J Med Life. 2014 Mar 15;7(1):55-9. Epub 2014 Mar 25.