PMID- 24654915
OWN - NLM
STAT- MEDLINE
DCOM- 20141203
LR  - 20220309
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 69
IP  - 5
DP  - 2014 May
TI  - Geographical variation in the prevalence of sensitization to common aeroallergens 
      in adults: the GA(2) LEN survey.
PG  - 643-51
LID - 10.1111/all.12397 [doi]
AB  - BACKGROUND: Geographical variation in the prevalence of sensitization to 
      aeroallergens may reflect differences in exposure to risk factors such as having 
      older siblings, being raised on a farm or other unidentified exposures. 
      OBJECTIVE: We wanted to measure geographical variation in skin prick test 
      positivity and assess whether it was explained by differences in family size 
      and/or farm exposure. We also compared prevalence in younger and older subjects. 
      METHODS: Within the Global Allergy and Asthma European Network (GA(2) LEN) 
      survey, we measured the prevalence of skin prick positivity to a panel of 
      allergens, and geometric mean serum total immunoglobulin E (IgE), in 3451 
      participants aged 18-75 years in 13 areas of Europe. Estimated prevalence was 
      standardized to account for study design. We compared prevalence estimates in 
      younger and older subjects and further adjusted for age, gender, smoking history, 
      farm exposure, number of older siblings and body mass index (BMI). RESULTS: Skin 
      prick test positivity to any one of the measured allergens varied within Europe 
      from 31.4% to 52.9%. Prevalence of sensitization to single allergens also varied. 
      Variation in serum total IgE was less marked. Younger participants had higher 
      skin prick sensitivity prevalence, but not total IgE, than older participants. 
      Geographical variation remained even after adjustment for confounders. 
      CONCLUSION: Geographical variation in the prevalence of skin prick test 
      positivity in Europe is unlikely to be explained by geographical variation in 
      gender, age, smoking history, farm exposure, family size and BMI. Higher 
      prevalence in younger, compared to older, adults may reflect cohort-associated 
      increases in sensitization or the influence of ageing on immune or tissue 
      responses.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Newson, R B
AU  - Newson RB
AD  - Respiratory Epidemiology and Public Health Group, National Heart and Lung 
      Institute, Imperial College London, London, UK.
FAU - van Ree, R
AU  - van Ree R
FAU - Forsberg, B
AU  - Forsberg B
FAU - Janson, C
AU  - Janson C
FAU - Lotvall, J
AU  - Lotvall J
FAU - Dahlen, S-E
AU  - Dahlen SE
FAU - Toskala, E M
AU  - Toskala EM
FAU - Baelum, J
AU  - Baelum J
FAU - Brozek, G M
AU  - Brozek GM
FAU - Kasper, L
AU  - Kasper L
FAU - Kowalski, M L
AU  - Kowalski ML
FAU - Howarth, P H
AU  - Howarth PH
FAU - Fokkens, W J
AU  - Fokkens WJ
FAU - Bachert, C
AU  - Bachert C
FAU - Keil, T
AU  - Keil T
FAU - Kramer, U
AU  - Kramer U
FAU - Bislimovska, J
AU  - Bislimovska J
FAU - Gjomarkaj, M
AU  - Gjomarkaj M
FAU - Loureiro, C
AU  - Loureiro C
FAU - Burney, P G J
AU  - Burney PG
FAU - Jarvis, D
AU  - Jarvis D
LA  - eng
GR  - G0400473/MRC_/Medical Research Council/United Kingdom
GR  - G0800766/MRC_/Medical Research Council/United Kingdom
GR  - G0900453/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20140321
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Air Pollutants)
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Air Pollutants/*adverse effects
MH  - Allergens/classification/*immunology
MH  - Animals
MH  - Female
MH  - Global Health/statistics & numerical data
MH  - Humans
MH  - Hypersensitivity/*epidemiology/*immunology
MH  - Immunoglobulin E/blood/immunology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Public Health Surveillance
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Global Allergy and Asthma European Network, Europe
OT  - geographical variation
OT  - prevalence
OT  - skin prick tests
OT  - total immunoglobulin E
EDAT- 2014/03/25 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/03/25 06:00
PHST- 2014/02/14 00:00 [accepted]
PHST- 2014/03/25 06:00 [entrez]
PHST- 2014/03/25 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1111/all.12397 [doi]
PST - ppublish
SO  - Allergy. 2014 May;69(5):643-51. doi: 10.1111/all.12397. Epub 2014 Mar 21.