PMID- 24655430
OWN - NLM
STAT- MEDLINE
DCOM- 20150226
LR  - 20140815
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 92
IP  - 6
DP  - 2014 Sep
TI  - Relationship between supernormal sectors of retinal nerve fibre layer and axial 
      length in normal eyes.
PG  - e481-7
LID - 10.1111/aos.12382 [doi]
AB  - PURPOSE: To determine the effect of the axial length on the supernormal and 
      false-positive sectors of the peripapillary retinal nerve fibre layer (RNFL) in 
      healthy eyes using the normative database embedded in a spectral domain optical 
      coherence tomographic (SD-OCT) instrument. METHODS: This was a prospective, 
      observational cross -sectional study. The right eyes of 126 healthy young 
      volunteers were studied. The RNFL thickness was measured by SD-OCT in twelve 
      30-degree sectors (clock hours) around the optic disc. The sectors whose RNFL 
      thickness was <5% probability level were labelled as false-positive sectors. The 
      sectors >95% probability level were labelled as supernormal sectors. The 
      relationships between the axial length and rates of supernormal and 
      false-positive sectors were investigated. RESULTS: A longer axial length was 
      significantly associated with an increase in the rates of supernormal thickness 
      in sector 8 (odds ratio, [OR], 1.494; p = 0.010) and sector 10 (OR, 1.529; 
      p = 0.008). The supernormal sectors were mainly located in the temporal region. A 
      longer axial length was significantly associated with a higher rates of false 
      positives in sector 5 (OR, 1.789; p = 0.017), sector 6 (OR, 2.305; p < 0.001) and 
      sector 12 (OR, 2.277; p = 0.035). CONCLUSIONS: The axial length was significantly 
      related to the rates of supernormal and false-positive sectors even in healthy 
      eyes. These findings indicate that the specificity and sensitivity of SD-OCT will 
      be affected especially in eyes with longer axial lengths.
CI  - (c) 2014 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & 
      Sons Ltd.
FAU - Yamashita, Takehiro
AU  - Yamashita T
AD  - Department of Ophthalmology, Kagoshima University Graduate School of Medical and 
      Dental Sciences, Kagoshima, Japan.
FAU - Kii, Yuya
AU  - Kii Y
FAU - Tanaka, Minoru
AU  - Tanaka M
FAU - Yoshinaga, Wakako
AU  - Yoshinaga W
FAU - Yamashita, Toshifumi
AU  - Yamashita T
FAU - Nakao, Kumiko
AU  - Nakao K
FAU - Sakamoto, Taiji
AU  - Sakamoto T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Observational Study
DEP - 20140321
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
SB  - IM
MH  - Adult
MH  - Aged
MH  - Axial Length, Eye/*anatomy & histology/pathology
MH  - Cross-Sectional Studies
MH  - False Positive Reactions
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Intraocular Pressure
MH  - Low Tension Glaucoma/diagnosis
MH  - Male
MH  - Myopia/complications
MH  - *Nerve Fibers
MH  - Optic Disk/*anatomy & histology/pathology
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Retinal Ganglion Cells/*cytology/pathology
MH  - Sensitivity and Specificity
MH  - Tomography, Optical Coherence
MH  - Young Adult
OTO - NOTNLM
OT  - RNFL colour code
OT  - glaucoma
OT  - myopia
OT  - pseudo-negative
OT  - pseudo-positive
OT  - retina
EDAT- 2014/03/25 06:00
MHDA- 2015/02/27 06:00
CRDT- 2014/03/25 06:00
PHST- 2013/11/27 00:00 [received]
PHST- 2014/01/29 00:00 [accepted]
PHST- 2014/03/25 06:00 [entrez]
PHST- 2014/03/25 06:00 [pubmed]
PHST- 2015/02/27 06:00 [medline]
AID - 10.1111/aos.12382 [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2014 Sep;92(6):e481-7. doi: 10.1111/aos.12382. Epub 2014 Mar 21.