PMID- 24655970
OWN - NLM
STAT- MEDLINE
DCOM- 20141209
LR  - 20151119
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 46
IP  - 2
DP  - 2014
TI  - Early microchimerism in peripheral blood following kidney transplantation.
PG  - 388-90
LID - S0041-1345(13)01432-2 [pii]
LID - 10.1016/j.transproceed.2013.12.036 [doi]
AB  - BACKGROUND: The role of microchimerism found in the peripheral blood of renal 
      transplant recipients remains a matter of debate. We assessed the frequency of 
      microchimerism after kidney transplantation and examined its influence on 
      clinical courses over a 12-month follow-up period. PATIENTS AND METHODS: Ten 
      single-kidney recipients underwent microchimerism detection at 2 days, 2 weeks, 
      and 1, 3, 6, and 12 months after transplantation, with mismatch human leukocyte 
      antigen (HLA)-A, -B, and -C used as markers. RESULTS: Microchimerism was detected 
      in 8 (80%) patients at 2 days after kidney transplantation. In 3 of those, 
      microchimerism became negative within 3 months after transplantation, whereas it 
      remained present for up to 12 months in 3 patients (33 %). There was 1 acute 
      rejection episode in a patient in whom microchimerism became negative within 3 
      months. Protocol renal graft biopsy specimens obtained 3 months after 
      transplantation revealed no acute cellular-mediated rejection (ACMR) or acute 
      antibody-mediated rejection (AAMR) in the 5 patients positive for microchimerism 
      at 3 months. CONCLUSIONS: Microchimerism was frequently detected after kidney 
      transplantation. Microchimerism that remained for more than 3 months 
      post-transplantation might be correlated with a lower incidence of rejection, 
      thus its monitoring may help identify recipients with a low rejection risk.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Kishikawa, H
AU  - Kishikawa H
AD  - Department of Renal Transplantation Center, Hyogo Prefectural Nishinomiya 
      Hospital, Nishinomiya, Hyogo, Japan. Electronic address: hidefumi69@hotmail.com.
FAU - Kinoshita, T
AU  - Kinoshita T
AD  - Department of Renal Transplantation Center, Hyogo Prefectural Nishinomiya 
      Hospital, Nishinomiya, Hyogo, Japan.
FAU - Yonemoto, S
AU  - Yonemoto S
AD  - Department of Renal Transplantation Center, Hyogo Prefectural Nishinomiya 
      Hospital, Nishinomiya, Hyogo, Japan.
FAU - Kawamura, M
AU  - Kawamura M
AD  - Department of Renal Transplantation Center, Hyogo Prefectural Nishinomiya 
      Hospital, Nishinomiya, Hyogo, Japan.
FAU - Nakazawa, S
AU  - Nakazawa S
AD  - Department of Renal Transplantation Center, Hyogo Prefectural Nishinomiya 
      Hospital, Nishinomiya, Hyogo, Japan.
FAU - Ueda, N
AU  - Ueda N
AD  - Department of Renal Transplantation Center, Hyogo Prefectural Nishinomiya 
      Hospital, Nishinomiya, Hyogo, Japan.
FAU - Hirai, T
AU  - Hirai T
AD  - Department of Renal Transplantation Center, Hyogo Prefectural Nishinomiya 
      Hospital, Nishinomiya, Hyogo, Japan.
FAU - Nishimura, K
AU  - Nishimura K
AD  - Department of Renal Transplantation Center, Hyogo Prefectural Nishinomiya 
      Hospital, Nishinomiya, Hyogo, Japan.
FAU - Hashimoto, M
AU  - Hashimoto M
AD  - Department of Renal Transplantation Center, Hyogo Prefectural Nishinomiya 
      Hospital, Nishinomiya, Hyogo, Japan.
FAU - Ichikawa, Y
AU  - Ichikawa Y
AD  - Department of Renal Transplantation Center, Hyogo Prefectural Nishinomiya 
      Hospital, Nishinomiya, Hyogo, Japan.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Biomarkers)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/*blood
MH  - *Chimerism
MH  - Female
MH  - HLA Antigens/blood/*genetics
MH  - Humans
MH  - *Kidney Transplantation
MH  - Male
MH  - Middle Aged
EDAT- 2014/03/25 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/03/25 06:00
PHST- 2013/09/20 00:00 [received]
PHST- 2013/12/01 00:00 [revised]
PHST- 2013/12/11 00:00 [accepted]
PHST- 2014/03/25 06:00 [entrez]
PHST- 2014/03/25 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S0041-1345(13)01432-2 [pii]
AID - 10.1016/j.transproceed.2013.12.036 [doi]
PST - ppublish
SO  - Transplant Proc. 2014;46(2):388-90. doi: 10.1016/j.transproceed.2013.12.036.