PMID- 24656654
OWN - NLM
STAT- MEDLINE
DCOM- 20150105
LR  - 20220330
IS  - 1532-8198 (Electronic)
IS  - 1092-9134 (Print)
IS  - 1092-9134 (Linking)
VI  - 18
IP  - 3
DP  - 2014 Jun
TI  - Antral atrophy, intestinal metaplasia, and preneoplastic markers in Mexican 
      children with Helicobacter pylori-positive and Helicobacter pylori-negative 
      gastritis.
PG  - 129-35
LID - S1092-9134(14)00008-2 [pii]
LID - 10.1016/j.anndiagpath.2014.02.003 [doi]
AB  - Chronic inflammation and infection are major risk factors for gastric 
      carcinogenesis in adults. As chronic gastritis is common in Mexican children, 
      diagnosis of Helicobacter pylori and other causes of gastritis are critical for 
      the identification of children who would benefit from closer surveillance. Antral 
      biopsies from 82 Mexican children (mean age, 8.3 +/- 4.8 years) with chronic 
      gastritis (36 H pylori+, 46 H pylori-) were examined for gastritis activity, 
      atrophy, intestinal metaplasia (IM), and immunohistochemical expression of 
      gastric carcinogenesis biomarkers caudal type homeobox 2 (CDX2), ephrin type-B 
      receptor 4 (EphB4), matrix metalloproteinase 3 (MMP3), macrophage migration 
      inhibitory factor (MIF), p53, beta-catenin, and E-cadherin. Atrophy was diagnosed in 
      7 (9%) of 82, and IM, in 5 (6%) of 82 by routine histology, whereas 6 additional 
      children (7%) (3 H pylori+) exhibited aberrant CDX2 expression without IM. 
      Significant positive correlations were seen between EphB4, MMP3, and MIF 
      (P<.0001). Atrophy and follicular pathology were more frequent in H pylori+ 
      biopsies (P<.0001), whereas IM and CDX2 expression showed no significant 
      correlation with H pylori status. Antral biopsies demonstrating atrophy, IM, 
      and/or aberrant CDX2 expression were seen in 21.95% (18/82) of the children, 
      potentially identifying those who would benefit from closer surveillance and 
      preventive dietary strategies. Biomarkers CDX2, EphB4, MMP3, and MIF may be 
      useful in the workup of pediatric gastritis.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Villarreal-Calderon, Rodolfo
AU  - Villarreal-Calderon R
AD  - Davidson Honors College, University of Montana, Missoula, MT 59812.
FAU - Luevano-Gonzalez, Arturo
AU  - Luevano-Gonzalez A
AD  - Department of Pathology, Clinical and Translational Research Core Lab, Medical 
      College of Wisconsin, Milwaukee, WI 53226.
FAU - Aragon-Flores, Mariana
AU  - Aragon-Flores M
AD  - Pathology Department, Hospital Central Militar, Mexico City, Mexico.
FAU - Zhu, Hongtu
AU  - Zhu H
AD  - Department of Biostatistics, University of North Carolina Gillings School of 
      Global Public Health, Chapel Hill, NC 27599.
FAU - Yuan, Ying
AU  - Yuan Y
AD  - Department of Biostatistics, University of North Carolina Gillings School of 
      Global Public Health, Chapel Hill, NC 27599.
FAU - Xiang, Qun
AU  - Xiang Q
AD  - Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI 
      53226.
FAU - Yan, Benjamin
AU  - Yan B
AD  - Department of Pathology, Clinical and Translational Research Core Lab, Medical 
      College of Wisconsin, Milwaukee, WI 53226.
FAU - Stoll, Kathryn Anne
AU  - Stoll KA
AD  - Department of Pathology, Clinical and Translational Research Core Lab, Medical 
      College of Wisconsin, Milwaukee, WI 53226.
FAU - Cross, Janet V
AU  - Cross JV
AD  - Department of Pathology, University of Virginia School of Medicine, 
      Charlottesville, VA, 22908.
FAU - Iczkowski, Kenneth A
AU  - Iczkowski KA
AD  - Department of Pathology, Clinical and Translational Research Core Lab, Medical 
      College of Wisconsin, Milwaukee, WI 53226.
FAU - Mackinnon, Alexander Craig Jr
AU  - Mackinnon AC Jr
AD  - Department of Pathology, Clinical and Translational Research Core Lab, Medical 
      College of Wisconsin, Milwaukee, WI 53226. Electronic address: 
      amackinnon@mcw.edu.
LA  - eng
GR  - UL1 RR031973/RR/NCRR NIH HHS/United States
GR  - 1UL1RR031973/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20140211
PL  - United States
TA  - Ann Diagn Pathol
JT  - Annals of diagnostic pathology
JID - 9800503
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adolescent
MH  - Aged
MH  - Aged, 80 and over
MH  - Atrophy/epidemiology/metabolism/pathology
MH  - Biomarkers/metabolism
MH  - Child
MH  - Child, Preschool
MH  - Comorbidity
MH  - Female
MH  - Gastritis/epidemiology/metabolism/*pathology
MH  - Helicobacter Infections/epidemiology/metabolism/*pathology
MH  - *Helicobacter pylori
MH  - Humans
MH  - Infant
MH  - Intestinal Diseases/epidemiology/metabolism/*pathology
MH  - Male
MH  - Mexico
MH  - Middle Aged
MH  - Population Surveillance
MH  - Precancerous Conditions/epidemiology/metabolism/*pathology
MH  - Pyloric Antrum/metabolism/*pathology
PMC - PMC4516036
MID - NIHMS683979
OTO - NOTNLM
OT  - Antral gastritis
OT  - Biomarkers
OT  - Child
OT  - Helicobacter pylori
OT  - Mexican
OT  - Surveillance
EDAT- 2014/03/25 06:00
MHDA- 2015/01/06 06:00
PMCR- 2015/07/27
CRDT- 2014/03/25 06:00
PHST- 2014/01/23 00:00 [received]
PHST- 2014/02/04 00:00 [accepted]
PHST- 2014/03/25 06:00 [entrez]
PHST- 2014/03/25 06:00 [pubmed]
PHST- 2015/01/06 06:00 [medline]
PHST- 2015/07/27 00:00 [pmc-release]
AID - S1092-9134(14)00008-2 [pii]
AID - 10.1016/j.anndiagpath.2014.02.003 [doi]
PST - ppublish
SO  - Ann Diagn Pathol. 2014 Jun;18(3):129-35. doi: 10.1016/j.anndiagpath.2014.02.003. 
      Epub 2014 Feb 11.