PMID- 24657596
OWN - NLM
STAT- MEDLINE
DCOM- 20140625
LR  - 20221207
IS  - 1873-5487 (Electronic)
IS  - 0188-4409 (Linking)
VI  - 45
IP  - 3
DP  - 2014 Apr
TI  - HLA-DR polymorphism and primary biliary cirrhosis: evidence from a meta-analysis.
PG  - 270-9
LID - S0188-4409(14)00040-X [pii]
LID - 10.1016/j.arcmed.2014.03.002 [doi]
AB  - BACKGROUND AND AIMS: We undertook this study to review and quantitatively analyze 
      the association between human leukocyte antigen (HLA) DR polymorphisms and 
      susceptibility of primary biliary cirrhosis (PBC). METHODS: All relevant 
      publications on the association between HLA-DR polymorphisms and PBC were 
      searched through June 2013. Odds ratios (OR) and confidence intervals (CI) for 
      the comparisons between case and control group were calculated. Statistical 
      analysis was performed using Stata 11.0 software. RESULTS: Nineteen articles (or 
      20 studies including the substudies) were identified. For DR*7 allele, the ORs 
      (95% CIs) were 1.530 (1.310, 1.788), 1.757 (1.285, 2.403) and 1.495 (1.211, 
      1.845) in overall, Asian and European populations, respectively. For DR*8 
      alleles, the ORs (95% CIs) were 3.158 (1.822, 5.475), 2.803 (2.420, 3.247) and 
      3.056 (2.573, 3.629) in Asian, American and European subgroups, respectively. The 
      subgroup analysis for DR*11 and DR*13 showed a significant association in Asian 
      and European population. For DR*12 and *15 alleles, the overall ORs (95% CIs) 
      were 0.551 (0.404, 0.753) and 0.721 (0.607, 0.857). However, in subgroup analysis 
      for DR*12 allele, the association was only found in Asian population. In 
      addition, statistical significance exists in American and European populations in 
      the subgroup analysis for DR*15 allele. CONCLUSION: Our meta-analysis suggested 
      that HLA-DR *7 and *8 allele polymorphisms contributed to the susceptibility of 
      PBC, whereas DR*11, *12, *13 and *15 allele polymorphisms are protective factors 
      in certain population.
CI  - Copyright (c) 2014 IMSS. Published by Elsevier Inc. All rights reserved.
FAU - Li, Man
AU  - Li M
AD  - Department of Epidemiology and Statistics, School of Public Health, Hebei Medical 
      University, Shijiazhuang, China.
FAU - Zheng, Hao
AU  - Zheng H
AD  - Department of Ultrasonography, Hebei Chest Hospital, Shijiazhuang, China.
FAU - Tian, Qing-bao
AU  - Tian QB
AD  - Department of Epidemiology and Statistics, School of Public Health, Hebei Medical 
      University, Shijiazhuang, China.
FAU - Rui, Mei-na
AU  - Rui MN
AD  - Department of Epidemiology and Statistics, School of Public Health, Hebei Medical 
      University, Shijiazhuang, China.
FAU - Liu, Dian-wu
AU  - Liu DW
AD  - Department of Epidemiology and Statistics, School of Public Health, Hebei Medical 
      University, Shijiazhuang, China. Electronic address: dwliu1956@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20140321
PL  - United States
TA  - Arch Med Res
JT  - Archives of medical research
JID - 9312706
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Alleles
MH  - Asian People
MH  - Genetic Predisposition to Disease
MH  - HLA-DR Antigens/*genetics/immunology
MH  - Humans
MH  - Liver Cirrhosis, Biliary/ethnology/*genetics/immunology
MH  - Polymorphism, Genetic
MH  - White People
OTO - NOTNLM
OT  - HLA
OT  - Meta-analysis
OT  - Polymorphism
OT  - Primary biliary cirrhosis
EDAT- 2014/03/25 06:00
MHDA- 2014/06/26 06:00
CRDT- 2014/03/25 06:00
PHST- 2013/09/22 00:00 [received]
PHST- 2014/02/26 00:00 [accepted]
PHST- 2014/03/25 06:00 [entrez]
PHST- 2014/03/25 06:00 [pubmed]
PHST- 2014/06/26 06:00 [medline]
AID - S0188-4409(14)00040-X [pii]
AID - 10.1016/j.arcmed.2014.03.002 [doi]
PST - ppublish
SO  - Arch Med Res. 2014 Apr;45(3):270-9. doi: 10.1016/j.arcmed.2014.03.002. Epub 2014 
      Mar 21.