PMID- 24658594
OWN - NLM
STAT- MEDLINE
DCOM- 20150611
LR  - 20220311
IS  - 1460-2385 (Electronic)
IS  - 0931-0509 (Linking)
VI  - 29
IP  - 9
DP  - 2014 Sep
TI  - Protein intake and kidney function in the middle-age population: contrast between 
      cross-sectional and longitudinal data.
PG  - 1733-40
LID - 10.1093/ndt/gfu056 [doi]
AB  - BACKGROUND: Protein intake is considered a determinant of glomerular filtration 
      rate (GFR). Urinary urea is an objective marker of protein intake. The 
      population-based study investigated, cross-sectionally and longitudinally, the 
      association of protein intake with GFR, indexed by estimated GFR (eGFR). METHODS: 
      Data were collected on overnight urinary urea, serum creatinine (S-cr), eGFR and 
      other variables in 1522 men and women aged 45-64 years who participated in the 
      Gubbio study (baseline). S-Cr, eGFR and other variables were re-assessed in 1144 
      of the 1425 survivors after 12-year follow-up. RESULTS: At baseline, mean +/- SD 
      was 84.0 +/- 11.4 mL/min x 1.73 m(2) for eGFR calculated by CKD-Epi equation and 
      1.34 +/- 0.57 g/day per kg of ideal weight for protein intake assessed by 
      measurements of overnight urine excretion of urea nitrogen. Cross-sectional 
      analyses of baseline data indicated a positive correlation of protein intake with 
      eGFR (R = 0.180, P < 0.001). In multi-variable regression, 1 g/day higher protein 
      intake related to 4.7 mL/min x 1.73 m(2) higher eGFR [95% confidence interval 
      (CI) = 3.7/5.7]. At follow-up, mean +/- SD of 12-year eGFR change was -11.6 +/- 9.0 
      mL/min x 1.73 m(2). Baseline protein intake correlated with more negative eGFR 
      change (R = -0.251, P < 0.001). In multi-variable regression, 1 g/day higher 
      protein intake related to -4.1 mL/min x 1.73 m(2) more negative eGFR change (95% 
      CI = -5.1/-3.1) and to 1.78 risk for incidence of eGFR < 60 mL/min x 1.73 m(2) 
      (95% CI = 1.15/2.78). CONCLUSIONS: In middle-aged adults, high protein intake is 
      associated cross-sectionally with higher GFR but longitudinally with greater GFR 
      decline over time.
CI  - (c) The Author 2014. Published by Oxford University Press on behalf of ERA-EDTA. 
      All rights reserved.
FAU - Cirillo, Massimo
AU  - Cirillo M
AD  - Department of Medicine and Surgery, University of Salerno, Salerno, Italy.
FAU - Lombardi, Cinzia
AU  - Lombardi C
AD  - Department of Medicine and Surgery, University of Salerno, Salerno, Italy.
FAU - Chiricone, Daniela
AU  - Chiricone D
AD  - Atella Hemodialysis Center, Orta di Atella, Italy.
FAU - De Santo, Natale G
AU  - De Santo NG
AD  - Department of Medicine, Second University of Naples, Naples, Italy.
FAU - Zanchetti, Alberto
AU  - Zanchetti A
AD  - Istituto Auxologico Italiano, University of Milan, Milan, Italy.
FAU - Bilancio, Giancarlo
AU  - Bilancio G
AD  - Department of Medicine and Surgery, University of Salerno, Salerno, Italy.
LA  - eng
PT  - Journal Article
DEP - 20140321
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European 
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
RN  - 0 (Dietary Proteins)
RN  - 8W8T17847W (Urea)
SB  - IM
CIN - Nephrol Dial Transplant. 2014 Sep;29(9):1624-7. PMID: 24981583
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - Dietary Proteins/*administration & dosage
MH  - Female
MH  - Glomerular Filtration Rate/*physiology
MH  - Humans
MH  - Kidney/*physiology
MH  - Kidney Function Tests
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Urea/*urine
OTO - NOTNLM
OT  - Gubbio study
OT  - creatinine
OT  - eGFR
OT  - protein intake
OT  - urea
EDAT- 2014/03/25 06:00
MHDA- 2015/06/13 06:00
CRDT- 2014/03/25 06:00
PHST- 2014/03/25 06:00 [entrez]
PHST- 2014/03/25 06:00 [pubmed]
PHST- 2015/06/13 06:00 [medline]
AID - gfu056 [pii]
AID - 10.1093/ndt/gfu056 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2014 Sep;29(9):1733-40. doi: 10.1093/ndt/gfu056. Epub 
      2014 Mar 21.