PMID- 24659493
OWN - NLM
STAT- MEDLINE
DCOM- 20150713
LR  - 20221207
IS  - 1720-8319 (Electronic)
IS  - 1594-0667 (Linking)
VI  - 26
IP  - 5
DP  - 2014 Oct
TI  - Alleviation of podocyte injury: the possible pathway implicated in 
      anti-inflammation of alpha-lipoic acid in type 2 diabetics.
PG  - 483-9
LID - 10.1007/s40520-014-0207-1 [doi]
AB  - BACKGROUND AND AIMS: The objective of this study is to observe the effect of 
      alpha-lipoic acid (ALA) on Pod injury by anti-inflammation and explore its 
      possible renal protective mechanism. METHODS: A total of 36 cases with type 2 
      diabetes with microalbuminuria and fasting plasma glucose (FPG) levels less than 
      9 mmol/L and glycated hemoglobin A1c (HbA1c) </=9.0 % were recruited to be treated 
      with ALA (600 mg, daily) for 6 months (group DA). Another 30 healthy individuals 
      were chosen as normal controls (group NC). The levels of serum creatinine (Cr), 
      FPG, and HbA1c were detected; blood pressure was recorded; and early morning 
      urine samples (corrected for urinary Cr) were collected for the examination of 
      urinary monocyte chemoattractant protein-1 (MCP-1), transforming growth factor-beta1 
      (TGF-beta1), podocalyxin (PCX), nephrin, albumin and Cr in group NC and group DA at 
      the baseline and the sixth month. RESULTS: The excretions of urinary MCP-1, 
      TGF-beta1, PCX, nephrin and albumin to Cr ratio (abbreviated as UMCR, UTCR, UPCR, 
      UNCR and UACR respectively) were significantly increased in group DA compared 
      with group NC (all P < 0.01), and after 6-month treatment, all indexes mentioned 
      above decreased markedly (P < 0.05), while FPG and HbA1c had no obvious changes. 
      Additionally, there was a positive correlation between UMCR, UTCR with UPCR, UNCR 
      and UACR, respectively (all P < 0.01). CONCLUSIONS: Anti-inflammation of ALA in 
      vivo and local kidney is implicated in the protection of glomerular Pod injury in 
      patients with type 2 diabetes.
FAU - Bao, Xi-He
AU  - Bao XH
AD  - Department of Endocrinology, Anhui Provincial Hospital Affiliated to Anhui 
      Medical University, Hefei, 230001, China.
FAU - Xu, Jiang
AU  - Xu J
FAU - Chen, Yan
AU  - Chen Y
FAU - Yang, Chun-Lin
AU  - Yang CL
FAU - Ye, Shan-Dong
AU  - Ye SD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140322
PL  - Germany
TA  - Aging Clin Exp Res
JT  - Aging clinical and experimental research
JID - 101132995
RN  - 0 (Albumins)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Blood Glucose)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Membrane Proteins)
RN  - 0 (Sialoglycoproteins)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 0 (nephrin)
RN  - 0 (podocalyxin)
RN  - 73Y7P0K73Y (Thioctic Acid)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Albumins/analysis
MH  - Anti-Inflammatory Agents/chemistry
MH  - Blood Glucose/analysis
MH  - Blood Pressure
MH  - Case-Control Studies
MH  - Chemokine CCL2/urine
MH  - Creatinine/blood/urine
MH  - Diabetes Mellitus, Type 2/*immunology
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Inflammation
MH  - Male
MH  - Membrane Proteins/urine
MH  - Middle Aged
MH  - Monocytes/cytology
MH  - Podocytes/cytology/*pathology
MH  - Sialoglycoproteins/urine
MH  - Signal Transduction
MH  - Thioctic Acid/*chemistry
MH  - Transforming Growth Factor beta1/urine
EDAT- 2014/03/25 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/03/25 06:00
PHST- 2013/10/23 00:00 [received]
PHST- 2014/02/24 00:00 [accepted]
PHST- 2014/03/25 06:00 [entrez]
PHST- 2014/03/25 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 10.1007/s40520-014-0207-1 [doi]
PST - ppublish
SO  - Aging Clin Exp Res. 2014 Oct;26(5):483-9. doi: 10.1007/s40520-014-0207-1. Epub 
      2014 Mar 22.