PMID- 24660556
OWN - NLM
STAT- MEDLINE
DCOM- 20140430
LR  - 20140325
IS  - 1341-8963 (Print)
IS  - 1341-8963 (Linking)
VI  - 48
IP  - 6
DP  - 2013 Dec
TI  - [The relationship between BDNF gene polymorphisms and alcoholics in Japan].
PG  - 407-14
AB  - As a help of the mechanism elucidation of alcoholism, we studied the relationship 
      between brain-derived neurotrophic factor (BDNF) rs6265, 270 C/T (ID number has 
      not yet been determined), and rs10835210 gene polymorphisms, which are reported 
      to be related to bipolar disorder, and alcoholics. We genotyped the three 
      polymorphisms in the BDNF gene using polymerase chain reaction (PCR)-restriction 
      fragment length polymorphism (RFLP) in 65 alcoholics and 71 healthy controls. In 
      this study, there was no significant difference in the frequency of rs6265 and 
      270 C/T polymorphisms between alcoholics and controls (P > 0.05). However, there 
      was a significant difference in the genotype frequency of rs10835210 polymorphism 
      between alcoholics and controls (P < 0.05), in which the CA heterozygote genotype 
      and A allele frequency was higher in alcoholics than in the controls. It suggests 
      the possibility that the BDNF rs10835210 gene polymorphism affects the etiology 
      of alcoholism.
FAU - Narita, Shin
AU  - Narita S
FAU - Nagahori, Kenta
AU  - Nagahori K
FAU - Yoshihara, Eiji
AU  - Yoshihara E
FAU - Nishizawa, Daisuke
AU  - Nishizawa D
FAU - Ikeda, Kazutaka
AU  - Ikeda K
FAU - Kawai, Atsuko
AU  - Kawai A
FAU - Iwahashi, Kazuhiko
AU  - Iwahashi K
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Arukoru Yakubutsu Igakkai Zasshi
JT  - Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & 
      drug dependence
JID - 9612304
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alcoholics/*psychology
MH  - Alcoholism/diagnosis/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - Young Adult
EDAT- 2014/03/26 06:00
MHDA- 2014/05/03 06:00
CRDT- 2014/03/26 06:00
PHST- 2014/03/26 06:00 [entrez]
PHST- 2014/03/26 06:00 [pubmed]
PHST- 2014/05/03 06:00 [medline]
PST - ppublish
SO  - Nihon Arukoru Yakubutsu Igakkai Zasshi. 2013 Dec;48(6):407-14.