PMID- 24660789
OWN - NLM
STAT- MEDLINE
DCOM- 20150318
LR  - 20181202
IS  - 1939-1498 (Electronic)
IS  - 0882-7974 (Linking)
VI  - 29
IP  - 2
DP  - 2014 Jun
TI  - The Val/Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene 
      predicts decline in perceptual speed in older adults.
PG  - 384-92
LID - 10.1037/a0035201 [doi]
AB  - The brain-derived neurotrophic factor (BDNF) promotes activity-dependent synaptic 
      plasticity, and contributes to learning and memory. We investigated whether a 
      common Val66Met missense polymorphism (rs6265) of the BDNF gene is associated 
      with individual differences in cognitive decline (marked by perceptual speed) in 
      old age. A total of 376 participants of the Berlin Aging Study, with a mean age 
      of 83.9 years at first occasion, were assessed longitudinally up to 11 times 
      across more than 13 years on the Digit-Letter task. Met carriers (n = 123, 34%) 
      showed steeper linear decline than Val homozygotes (n = 239, 66%); the 
      corresponding contrast explained 2.20% of the variance in change in the entire 
      sample, and 3.41% after excluding individuals at risk for dementia. These effects 
      were not moderated by sex or socioeconomic status. Results are consistent with 
      the hypothesis that normal aging magnifies the effects of common genetic 
      variation on cognitive functioning.
CI  - PsycINFO Database Record (c) 2014 APA, all rights reserved.
FAU - Ghisletta, Paolo
AU  - Ghisletta P
AD  - Faculty of Psychology and Educational Sciences, University of Geneva.
FAU - Backman, Lars
AU  - Backman L
AD  - Aging Research Center, Karolinska Institute.
FAU - Bertram, Lars
AU  - Bertram L
AD  - Neuropsychiatric Genetics Group, Max Planck Institute for Molecular Genetics.
FAU - Brandmaier, Andreas Markus
AU  - Brandmaier AM
AD  - Center for Lifespan Psychology, Max Planck Institute for Human Development.
FAU - Gerstorf, Denis
AU  - Gerstorf D
AD  - Department of Psychology, Humboldt University.
FAU - Liu, Tian
AU  - Liu T
AD  - Center for Lifespan Psychology, Max Planck Institute for Human Development.
FAU - Lindenberger, Ulman
AU  - Lindenberger U
AD  - Center for Lifespan Psychology, Max Planck Institute for Human Development.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140324
PL  - United States
TA  - Psychol Aging
JT  - Psychology and aging
JID - 8904079
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*genetics/physiology/*psychology
MH  - Berlin
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cognition/*physiology
MH  - Female
MH  - Homozygote
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Methionine/*genetics
MH  - Mutation, Missense/genetics
MH  - Polymorphism, Genetic/*genetics
MH  - Reaction Time/genetics/physiology
MH  - Sex Characteristics
MH  - Social Class
MH  - Valine/*genetics
EDAT- 2014/03/26 06:00
MHDA- 2015/03/19 06:00
CRDT- 2014/03/26 06:00
PHST- 2014/03/26 06:00 [entrez]
PHST- 2014/03/26 06:00 [pubmed]
PHST- 2015/03/19 06:00 [medline]
AID - 2014-10111-001 [pii]
AID - 10.1037/a0035201 [doi]
PST - ppublish
SO  - Psychol Aging. 2014 Jun;29(2):384-92. doi: 10.1037/a0035201. Epub 2014 Mar 24.