PMID- 24661433
OWN - NLM
STAT- MEDLINE
DCOM- 20141229
LR  - 20140505
IS  - 1879-3231 (Electronic)
IS  - 0093-691X (Linking)
VI  - 81
IP  - 9
DP  - 2014 Jun
TI  - Gross placental morphology and foal serum biochemistry as predictors of foal 
      health.
PG  - 1293-9
LID - S0093-691X(14)00107-1 [pii]
LID - 10.1016/j.theriogenology.2014.02.011 [doi]
AB  - The aim of this study was to verify if changes in blood glucose, creatinine, 
      urea, and fibrinogen concentrations evaluated at birth reflect gross placenta 
      abnormalities, and are useful to identify foals that suffered from placental 
      dysfunction. A total of 92 mares were included in the present study: 68 delivered 
      healthy foals and they were included in group 1; 24 delivered sick foals and they 
      were included in group 2. In group 2, foals' clinical diagnoses included 
      perinatal asphyxia syndrome (PAS; n = 20) and prematurity and/or dysmaturity (n = 
      4). The proportion of sick foals was greater when placental abnormalities were 
      observed (chi(2) [1, n = 89] = 5.00; P = 0.025). Serum creatinine concentration at 
      birth was higher in sick than in healthy foals (P = 0.003), and blood glucose 
      concentrations at birth was smaller in sick than in healthy foals (P = 0.007). No 
      difference was found in blood chemistry results between survivors and 
      nonsurvivors of group 2. Serum creatinine concentration was higher in foals born 
      from grossly abnormal than in foals born from grossly normal placenta (P = 
      0.029), and it was higher in foals affected by PAS (311.17 mumol/L) than in 
      healthy foals (238.24 mumol/L) (P = 0.004). In a clinical setting, serum 
      creatinine and blood glucose concentrations should be evaluated at birth, 
      particularly in foals born from grossly abnormal placenta. The association of 
      clinical and laboratory data could be particularly important to promptly identify 
      and treat foals with a higher risk to develop PAS.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Pirrone, A
AU  - Pirrone A
AD  - Department of Veterinary Medical Science, University of Bologna, Ozzano 
      dell'Emilia, Bologna, Italy. Electronic address: alessandro.pirrone2@unibo.it.
FAU - Antonelli, C
AU  - Antonelli C
AD  - Department of Veterinary Medical Science, University of Bologna, Ozzano 
      dell'Emilia, Bologna, Italy.
FAU - Mariella, J
AU  - Mariella J
AD  - Department of Veterinary Medical Science, University of Bologna, Ozzano 
      dell'Emilia, Bologna, Italy.
FAU - Castagnetti, C
AU  - Castagnetti C
AD  - Department of Veterinary Medical Science, University of Bologna, Ozzano 
      dell'Emilia, Bologna, Italy.
LA  - eng
PT  - Journal Article
DEP - 20140222
PL  - United States
TA  - Theriogenology
JT  - Theriogenology
JID - 0421510
RN  - 0 (Blood Glucose)
RN  - 8W8T17847W (Urea)
RN  - 9001-32-5 (Fibrinogen)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Blood Glucose
MH  - Creatinine/blood
MH  - Female
MH  - Fibrinogen/metabolism
MH  - Horses/*blood/*physiology
MH  - Placenta/*anatomy & histology
MH  - Pregnancy
MH  - Urea/blood
OTO - NOTNLM
OT  - Foal
OT  - Hematobiochemical parameter
OT  - Perinatal asphyxia syndrome
OT  - Placenta
EDAT- 2014/03/26 06:00
MHDA- 2014/12/30 06:00
CRDT- 2014/03/26 06:00
PHST- 2013/07/15 00:00 [received]
PHST- 2014/02/20 00:00 [revised]
PHST- 2014/02/20 00:00 [accepted]
PHST- 2014/03/26 06:00 [entrez]
PHST- 2014/03/26 06:00 [pubmed]
PHST- 2014/12/30 06:00 [medline]
AID - S0093-691X(14)00107-1 [pii]
AID - 10.1016/j.theriogenology.2014.02.011 [doi]
PST - ppublish
SO  - Theriogenology. 2014 Jun;81(9):1293-9. doi: 10.1016/j.theriogenology.2014.02.011. 
      Epub 2014 Feb 22.