PMID- 24661939
OWN - NLM
STAT- MEDLINE
DCOM- 20141215
LR  - 20161125
IS  - 1532-2777 (Electronic)
IS  - 0306-9877 (Linking)
VI  - 82
IP  - 6
DP  - 2014 Jun
TI  - Biological basis of neuroprotection and neurotherapeutic effects of Whole Body 
      Periodic Acceleration (pGz).
PG  - 681-7
LID - S0306-9877(14)00104-2 [pii]
LID - 10.1016/j.mehy.2014.02.031 [doi]
AB  - Exercise is a well known neuroprotective and neurotherapeutic strategy in animal 
      models and humans with brain injury and cognitive dysfunction. In part, exercise 
      induced beneficial effects relate to endothelial derived nitric oxide (eNO) 
      production and induction of the neurotrophins; Brain Derived Neurotrophic Factor 
      (BDNF) and Glial Derived Neurotrophic Factor (GDNF). Whole Body Periodic 
      Acceleration (WBPA (pGz), is the motion of the supine body headward to footward 
      in a sinusoidal fashion, at frequencies of 100-160 cycles/min, inducing pulsatile 
      shear stress to the vascular endothelium. WBPA (pGz) increases eNO in the 
      cardiovascular system in animal models and humans. We hypothesized that WBPA 
      (pGz) has neuroprotective and neurotherapeutic effects due to enhancement of 
      biological pathways that include eNOS, BDNF and GDNF. We discuss protein 
      expression analysis of these in brain of rodents. Animal and observational human 
      data affirm a neuroprotective and neurotherapeutic role for WBPA (pGz). These 
      findings suggest that WBPA (pGz) in addition to its well known beneficial 
      cardiovascular effects can be a simple non-invasive neuroprotective and 
      neurotherapeutic strategy with far reaching health benefits.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Adams, Jose A
AU  - Adams JA
AD  - Division of Neonatology and Department of Research, Mount Sinai Medical Center, 
      Miami Beach, FL, United States. Electronic address: Tony-adams@msmc.com.
FAU - Uryash, Arkady
AU  - Uryash A
AD  - Division of Neonatology and Department of Research, Mount Sinai Medical Center, 
      Miami Beach, FL, United States.
FAU - Bassuk, Jorge
AU  - Bassuk J
AD  - Division of Neonatology and Department of Research, Mount Sinai Medical Center, 
      Miami Beach, FL, United States.
FAU - Sackner, Marvin A
AU  - Sackner MA
AD  - Clinical Professor of Medicine, University of Miami School of Medicine, Miami, 
      FL, United States.
FAU - Kurlansky, Paul
AU  - Kurlansky P
AD  - Columbia University College of Physicians and Surgeons, NY, United States.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140312
PL  - United States
TA  - Med Hypotheses
JT  - Medical hypotheses
JID - 7505668
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factors)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - *Acceleration
MH  - Animals
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Glial Cell Line-Derived Neurotrophic Factors/*metabolism
MH  - Humans
MH  - Mice
MH  - Musculoskeletal Manipulations/*methods
MH  - Nervous System Physiological Phenomena/*physiology
MH  - Nitric Oxide/*metabolism
MH  - Rats
EDAT- 2014/03/26 06:00
MHDA- 2014/12/17 06:00
CRDT- 2014/03/26 06:00
PHST- 2014/01/29 00:00 [received]
PHST- 2014/02/20 00:00 [revised]
PHST- 2014/02/26 00:00 [accepted]
PHST- 2014/03/26 06:00 [entrez]
PHST- 2014/03/26 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
AID - S0306-9877(14)00104-2 [pii]
AID - 10.1016/j.mehy.2014.02.031 [doi]
PST - ppublish
SO  - Med Hypotheses. 2014 Jun;82(6):681-7. doi: 10.1016/j.mehy.2014.02.031. Epub 2014 
      Mar 12.