PMID- 24662570
OWN - NLM
STAT- MEDLINE
DCOM- 20150623
LR  - 20220310
IS  - 1536-3724 (Electronic)
IS  - 1050-642X (Linking)
VI  - 24
IP  - 6
DP  - 2014 Nov
TI  - Influence of aerobic training and detraining on serum BDNF, insulin resistance, 
      and metabolic risk factors in middle-aged men diagnosed with metabolic syndrome.
PG  - 513-8
LID - 10.1097/JSM.0000000000000082 [doi]
AB  - OBJECTIVE: To study the influence of aerobic exercise training on brain-derived 
      neurotrophic factor (BDNF), insulin resistance, and lipid profile in middle-aged 
      men diagnosed with metabolic syndrome (MetS). DESIGN: This is an experimental 
      repeated measure study. SETTING: Subjects participated in aerobic training 
      programs (18 sessions of 25-40 minutes per session) in Guilan University 
      gymnasium and court. PARTICIPANTS: A total of 21 middle-aged men (50-65 years 
      old) diagnosed with MetS participated. INTERVENTIONS: We randomly divided 21 
      middle-aged men with MetS into exercise and control groups. The exercise group 
      followed an aerobic training program (18 sessions, 3/wk) at 50% to 60% of 
      V[Combining Dot Above]O2 peak (25-40 minutes per session) and 6 weeks of 
      detraining. Blood samples were collected at baseline, end of the training, and 
      detraining. MAIN OUTCOME MEASURES: High BDNF level in patients with MetS and its 
      reduction after chronic aerobic exercise. RESULTS: Aerobic training significantly 
      decreased all the metabolic risk factors, including overall MetS z score, insulin 
      resistance, and lipid profile (P < 0.05). After the detraining period, plasma 
      triglyceride, high-density lipoprotein, and also overall MetS z score remained 
      unchanged (P < 0.05); however, serum BDNF, which was decreased by aerobic 
      training (P = 0.013), restored to the baseline at the end of the detraining (P = 
      0.018). CONCLUSIONS: Improved metabolic risk factors along with decreased serum 
      BDNF in response to aerobic training and the opposite direction during the 
      detraining emphasize the importance of physical activity in the treatment of MetS 
      and prevention of related diseases.
FAU - Damirchi, Arsalan
AU  - Damirchi A
AD  - *Department of Sport Physiology, Faculty of Physical Education and Sport 
      Sciences, University of Guilan, Rasht, Iran; daggerCellular and Molecular Research 
      Center, Guilan University of Medical Sciences, Rasht, Iran; double daggerDepartment of 
      Physical Education and Sport Sciences, Faculty of Psychology and Education, 
      Azarbaijan Shahid Madani University, Tabriz, Iran; and  section signDepartment of Physiology, 
      Guilan University of Medical Sciences, Rasht, Iran.
FAU - Tehrani, Bahram Soltani
AU  - Tehrani BS
FAU - Alamdari, Karim Azali
AU  - Alamdari KA
FAU - Babaei, Parvin
AU  - Babaei P
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin J Sport Med
JT  - Clinical journal of sport medicine : official journal of the Canadian Academy of 
      Sport Medicine
JID - 9103300
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Triglycerides)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cholesterol, HDL/blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Exercise Therapy/*methods
MH  - Humans
MH  - *Insulin Resistance
MH  - Male
MH  - Metabolic Syndrome/blood/etiology/*therapy
MH  - Middle Aged
MH  - Risk Factors
MH  - Treatment Outcome
MH  - Triglycerides/blood
EDAT- 2014/03/26 06:00
MHDA- 2015/06/24 06:00
CRDT- 2014/03/26 06:00
PHST- 2014/03/26 06:00 [entrez]
PHST- 2014/03/26 06:00 [pubmed]
PHST- 2015/06/24 06:00 [medline]
AID - 10.1097/JSM.0000000000000082 [doi]
PST - ppublish
SO  - Clin J Sport Med. 2014 Nov;24(6):513-8. doi: 10.1097/JSM.0000000000000082.