PMID- 24662838
OWN - NLM
STAT- MEDLINE
DCOM- 20141230
LR  - 20211021
IS  - 1536-5166 (Electronic)
IS  - 1070-8022 (Print)
IS  - 1070-8022 (Linking)
VI  - 34
IP  - 2
DP  - 2014 Jun
TI  - Assessment of optic nerve head drusen using enhanced depth imaging and swept 
      source optical coherence tomography.
PG  - 198-205
LID - 10.1097/WNO.0000000000000115 [doi]
AB  - BACKGROUND: Optic nerve head drusen (ONHD) are calcific deposits buried or at the 
      surface of the optic disc. Although ONHD may be associated with progressive 
      visual field defects, the mechanism of drusen-related field loss is poorly 
      understood. Methods for detecting and imaging disc drusen include B-scan 
      ultrasonography, fundus autofluorescence, and optical coherence tomography (OCT). 
      These modalities are useful for drusen detection but are limited by low 
      resolution or poor penetration of deep structures. This review was designed to 
      assess the potential role of new OCT technologies in imaging ONHD. EVIDENCE 
      ACQUISITION: Critical appraisal of published literature and comparison of new 
      imaging devices to established technology. RESULTS: The new imaging modalities of 
      enhanced depth imaging optical coherence tomography (EDI-OCT) and swept source 
      optical coherence tomography (SS-OCT) are able to provide unprecedented in vivo 
      detail of ONHD. Using these devices it is now possible to quantify optic disc 
      drusen dimensions and assess integrity of neighboring retinal structures, 
      including the retinal nerve fiber layer. CONCLUSIONS: EDI-OCT and SS-OCT have the 
      potential to allow better detection of longitudinal changes in drusen and neural 
      retina and improve our understanding of drusen-related visual field loss.
FAU - Silverman, Anna L
AU  - Silverman AL
AD  - Department of Ophthalmology, Hamilton Glaucoma Center, University of California, 
      San Diego, California.
FAU - Tatham, Andrew J
AU  - Tatham AJ
FAU - Medeiros, Felipe A
AU  - Medeiros FA
FAU - Weinreb, Robert N
AU  - Weinreb RN
LA  - eng
GR  - R01 EY011008/EY/NEI NIH HHS/United States
GR  - P30 EY022589/EY/NEI NIH HHS/United States
GR  - P30EY022589/EY/NEI NIH HHS/United States
GR  - R01 EY021818/EY/NEI NIH HHS/United States
GR  - EY021818/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Neuroophthalmol
JT  - Journal of neuro-ophthalmology : the official journal of the North American 
      Neuro-Ophthalmology Society
JID - 9431308
SB  - IM
MH  - *Diagnostic Imaging
MH  - Humans
MH  - Optic Disk Drusen/complications/*diagnosis/etiology
MH  - Perceptual Disorders/etiology
MH  - *Tomography, Optical Coherence
MH  - Visual Fields/physiology
PMC - PMC4523639
MID - NIHMS709860
EDAT- 2014/03/26 06:00
MHDA- 2014/12/31 06:00
PMCR- 2015/08/04
CRDT- 2014/03/26 06:00
PHST- 2014/03/26 06:00 [entrez]
PHST- 2014/03/26 06:00 [pubmed]
PHST- 2014/12/31 06:00 [medline]
PHST- 2015/08/04 00:00 [pmc-release]
AID - 10.1097/WNO.0000000000000115 [doi]
PST - ppublish
SO  - J Neuroophthalmol. 2014 Jun;34(2):198-205. doi: 10.1097/WNO.0000000000000115.