PMID- 24663244
OWN - NLM
STAT- MEDLINE
DCOM- 20150115
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 3
DP  - 2014
TI  - Serum BDNF levels in relation to illness severity, suicide attempts, and central 
      serotonin activity in patients with major depressive disorder: a pilot study.
PG  - e91061
LID - 10.1371/journal.pone.0091061 [doi]
LID - e91061
AB  - The aim of this study was to test the hypothesis that serum levels of 
      brain-derived neurotrophic factor (BDNF) are correlated with the loudness 
      dependence of auditory evoked potentials (LDAEP). The question of whether there 
      is a difference in BDNF levels between depressive patients according to their 
      illness severity, history of suicide attempts, and central serotonin activity was 
      also addressed. A sample of 51 patients who met the criteria for major depressive 
      disorder following diagnosis using axis I of the fourth edition of the Diagnostic 
      and Statistical Manual of Mental Disorders - text revision comprised the study 
      subjects. The patients were stratified into two subgroups based on their illness 
      severity, history of suicide attempts, and their LDAEP values. The LDAEP was 
      evaluated by measuring the auditory event-related potentials, and serum BDNF was 
      measured using blood sampling before beginning medication with serotonergic 
      agents. There was no difference in serum BDNF levels between the two patient 
      subgroups. The subgroup with moderate-to-severe depression (n = 16) was 
      reanalyzed after stratifying it into two subgroups according to LDAEP and BDNF 
      values (dichotomized at the medians into low and high). The high-LDAEP subgroup 
      had higher serum BDNF levels and total Barratt Impulsiveness Scale score than the 
      low-LDAEP subgroup (p = 0.03 and 0.036, respectively). Serum BDNF levels were 
      positively correlated with LDAEP and total Beck Hopelessness Scale (BHS) score 
      (r = 0.56, p = 0.025, and r = 0.59, p = 0.016, respectively). The high-BDNF 
      subgroup had a higher LDAEP and total BHS score than the low-BDNF subgroup 
      (p = 0.046 and p = 0.011, respectively). This is the first study to demonstrate a 
      relationship between the BDNF level and LDAEP in Asian depressive patients. 
      Intriguingly, the high-BDNF subgroup (divided according to illness severity) 
      exhibited a more severe psychopathology on some psychometric rating scales, a 
      finding that conflicts with previous results.
FAU - Park, Young-Min
AU  - Park YM
AD  - Department of Psychiatry, Ilsan Paik Hospital, Inje University College of 
      Medicine, Goyang, Republic of Korea.
FAU - Lee, Bun-Hee
AU  - Lee BH
AD  - Department of Psychiatry, Gangnam Eulji Hospital, Eulji University, Seoul, 
      Republic of Korea.
FAU - Um, Tae Hyun
AU  - Um TH
AD  - Department of Laboratory Medicine, Ilsan Paik Hospital, Inje University College 
      of Medicine, Goyang, Republic of Korea.
FAU - Kim, Sollip
AU  - Kim S
AD  - Department of Laboratory Medicine, Ilsan Paik Hospital, Inje University College 
      of Medicine, Goyang, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140324
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depressive Disorder, Major/*blood/metabolism/*physiopathology
MH  - Evoked Potentials, Auditory
MH  - Female
MH  - Humans
MH  - Loudness Perception/physiology
MH  - Male
MH  - Pilot Projects
MH  - Psychometrics
MH  - Serotonin/*metabolism
MH  - *Suicide, Attempted
PMC - PMC3963843
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/03/26 06:00
MHDA- 2015/01/16 06:00
PMCR- 2014/03/24
CRDT- 2014/03/26 06:00
PHST- 2013/07/04 00:00 [received]
PHST- 2014/02/08 00:00 [accepted]
PHST- 2014/03/26 06:00 [entrez]
PHST- 2014/03/26 06:00 [pubmed]
PHST- 2015/01/16 06:00 [medline]
PHST- 2014/03/24 00:00 [pmc-release]
AID - PONE-D-13-27541 [pii]
AID - 10.1371/journal.pone.0091061 [doi]
PST - epublish
SO  - PLoS One. 2014 Mar 24;9(3):e91061. doi: 10.1371/journal.pone.0091061. eCollection 
      2014.