PMID- 24663245
OWN - NLM
STAT- MEDLINE
DCOM- 20141121
LR  - 20240314
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 3
DP  - 2014
TI  - Multiple white matter volume reductions in patients with panic disorder: 
      relationships between orbitofrontal Gyrus volume and symptom severity and social 
      dysfunction.
PG  - e92862
LID - 10.1371/journal.pone.0092862 [doi]
LID - e92862
AB  - Numerous brain regions are believed to be involved in the neuropathology of panic 
      disorder (PD) including fronto-limbic regions, thalamus, brain stem, and 
      cerebellum. However, while several previous studies have demonstrated volumetric 
      gray matter reductions in these brain regions, there have been no studies 
      evaluating volumetric white matter changes in the fiber bundles connecting these 
      regions. In addition, although patients with PD typically exhibit social, 
      interpersonal and occupational dysfunction, the neuropathologies underlying these 
      dysfunctions remain unclear. A voxel-based morphometry study was conducted to 
      evaluate differences in regional white matter volume between 40 patients with PD 
      and 40 healthy control subjects (HC). Correlation analyses were performed between 
      the regional white matter volumes and patients' scores on the Panic Disorder 
      Severity Scale (PDSS) and the Global Assessment of Functioning (GAF). Patients 
      with PD demonstrated significant volumetric reductions in widespread white matter 
      regions including fronto-limbic, thalamo-cortical and cerebellar pathways 
      (p<0.05, FDR corrected). Furthermore, there was a significant negative 
      relationship between right orbitofrontal gyrus (OFG) white matter volume and the 
      severity of patients' clinical symptoms, as assessed with the PDSS. A significant 
      positive relationship was also observed between patients' right OFG volumes and 
      their scores on the GAF. Our results suggest that volumetric reductions in 
      widespread white matter regions may play an important role in the pathology of 
      PD. In particular, our results suggest that structural white matter abnormalities 
      in the right OFG may contribute to the social, personal and occupational 
      dysfunction typically experienced by patients with PD.
FAU - Konishi, Jun
AU  - Konishi J
AD  - Department of Psychiatry, Graduate School of Medicine, Yokohama City University, 
      Yokohama, Japan.
FAU - Asami, Takeshi
AU  - Asami T
AD  - Department of Psychiatry, Graduate School of Medicine, Yokohama City University, 
      Yokohama, Japan.
FAU - Hayano, Fumi
AU  - Hayano F
AD  - Department of Psychiatry, Graduate School of Medicine, Yokohama City University, 
      Yokohama, Japan.
FAU - Yoshimi, Asuka
AU  - Yoshimi A
AD  - Department of Psychiatry, Graduate School of Medicine, Yokohama City University, 
      Yokohama, Japan.
FAU - Hayasaka, Shunsuke
AU  - Hayasaka S
AD  - Department of Psychiatry, Graduate School of Medicine, Yokohama City University, 
      Yokohama, Japan.
FAU - Fukushima, Hiroshi
AU  - Fukushima H
AD  - Department of Psychiatry, Graduate School of Medicine, Yokohama City University, 
      Yokohama, Japan.
FAU - Whitford, Thomas J
AU  - Whitford TJ
AD  - School of Psychology, University of New South Wales, Sydney, New South Wales, 
      Australia.
FAU - Inoue, Tomio
AU  - Inoue T
AD  - Department of Radiology, Graduate School of Medicine, Yokohama City University, 
      Yokohama, Japan.
FAU - Hirayasu, Yoshio
AU  - Hirayasu Y
AD  - Department of Psychiatry, Graduate School of Medicine, Yokohama City University, 
      Yokohama, Japan.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140324
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Cerebral Cortex/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Organ Size
MH  - Panic Disorder/*diagnostic imaging/drug therapy
MH  - Radiography
MH  - *Severity of Illness Index
MH  - Social Behavior Disorders/*diagnostic imaging/drug therapy
PMC - PMC3963974
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/03/26 06:00
MHDA- 2014/12/15 06:00
PMCR- 2014/03/24
CRDT- 2014/03/26 06:00
PHST- 2013/10/23 00:00 [received]
PHST- 2014/02/26 00:00 [accepted]
PHST- 2014/03/26 06:00 [entrez]
PHST- 2014/03/26 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PHST- 2014/03/24 00:00 [pmc-release]
AID - PONE-D-13-43360 [pii]
AID - 10.1371/journal.pone.0092862 [doi]
PST - epublish
SO  - PLoS One. 2014 Mar 24;9(3):e92862. doi: 10.1371/journal.pone.0092862. eCollection 
      2014.