PMID- 24664620
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140622
LR  - 20211021
IS  - 1869-6953 (Print)
IS  - 1869-6961 (Electronic)
IS  - 1869-6961 (Linking)
VI  - 5
IP  - 1
DP  - 2014 Jun
TI  - Efficacy of liraglutide in a real-life cohort.
PG  - 193-206
LID - 10.1007/s13300-014-0062-2 [doi]
AB  - INTRODUCTION: In the Liraglutide Effect and Action in Diabetes (LEAD) randomized 
      clinical trials (RCTs) assessing liraglutide in type 2 diabetes mellitus (T2DM), 
      glycated hemoglobin (A1c) was reduced by 7-16 mmol/mol and weight by up to 
      3.4 kg. As real-life efficacy data on liraglutide is limited, the authors 
      assessed clinical effects in a real-life cohort. METHODS: In this retrospective 
      analysis from the Israeli Health Maintenance Organization Maccabi, of patients 
      with T2DM, treated with liraglutide >/=6 months during 2011-2012, evaluations were 
      performed at baseline and 6 months. RESULTS: Insulin-naive patients (n = 1,101) 
      treated with liraglutide with at least one A1c or weight measurement were 
      identified. In 933 patients with an additional A1c value after 6 months, A1c 
      decreased by 9 mmol/mol (p < 0.0001, 95% CI 7-11) from 72 mmol/mol. In patients 
      receiving >2 oral antidiabetic drugs (OADs) prior to liraglutide treatment (80.7% 
      patients), A1c decreased by 7 mmol/mol, and in those receiving </=2 OADs, by 
      12 mmol/mol. In 453 patients with baseline data available, weight decreased by 
      2.55 kg (p < 0.0001); 173 patients (38.18%) achieved >/=1% A1c reduction. 
      Furthermore, 91 patients (20.1%) achieved National Institute for Health and Care 
      Excellence (NICE) criteria (decreased A1c >/=1%; weight >/=3%). Weight reduction was 
      marginally correlated with A1c reduction. CONCLUSIONS: Evidence from real-life 
      use of liraglutide demonstrated clinical effects similar to those demonstrated in 
      RCTs.
FAU - Heymann, Anthony
AU  - Heymann A
AD  - Family Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Maor, Yasmin
AU  - Maor Y
FAU - Goldstein, Inbal
AU  - Goldstein I
FAU - Todorova, Lora
AU  - Todorova L
FAU - Schertz-Sternberg, Perlit
AU  - Schertz-Sternberg P
FAU - Karasik, Avraham
AU  - Karasik A
LA  - eng
PT  - Journal Article
DEP - 20140325
PL  - United States
TA  - Diabetes Ther
JT  - Diabetes therapy : research, treatment and education of diabetes and related 
      disorders
JID - 101539025
EIN - Diabetes Ther. 2014 Jun;5(1):345. PMID: 24867237
PMC - PMC4065284
EDAT- 2014/03/26 06:00
MHDA- 2014/03/26 06:01
PMCR- 2014/03/25
CRDT- 2014/03/26 06:00
PHST- 2014/02/05 00:00 [received]
PHST- 2014/03/26 06:00 [entrez]
PHST- 2014/03/26 06:00 [pubmed]
PHST- 2014/03/26 06:01 [medline]
PHST- 2014/03/25 00:00 [pmc-release]
AID - 62 [pii]
AID - 10.1007/s13300-014-0062-2 [doi]
PST - ppublish
SO  - Diabetes Ther. 2014 Jun;5(1):193-206. doi: 10.1007/s13300-014-0062-2. Epub 2014 
      Mar 25.