PMID- 24664704
OWN - NLM
STAT- MEDLINE
DCOM- 20140724
LR  - 20220318
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 801
DP  - 2014
TI  - Impairment of the ubiquitin-proteasome pathway in RPE alters the expression of 
      inflammation related genes.
PG  - 237-50
LID - 10.1007/978-1-4614-3209-8_31 [doi]
AB  - The ubiquitin-proteasome pathway (UPP) plays an important role in regulating gene 
      expression. Retinal pigment epithelial cells (RPE) are a major source of ocular 
      inflammatory cytokines. In this work we determined the relationship between 
      impairment of the UPP and expression of inflammation-related factors. The UPP 
      could be impaired by oxidative stress or chemical inhibition. Impairment of the 
      UPP in RPE increased the expression of several inflammatory cytokines, such as 
      IL-6 and IL-8. However, the expression of monocyte chemoattractant protein-1 
      (MCP-1) and complement factor H (CFH) and was reduced upon impairment of the UPP. 
      These data suggest that impairment of the UPP in RPE may be one of the causes of 
      retinal inflammation and abnormal functions of monocyte and the complement system 
      during the pathogenesis of age-related macular degeneration.
FAU - Liu, Zhenzhen
AU  - Liu Z
AD  - Laboratory for Nutrition and Vision Research, Jean Mayer USDA Human Nutrition 
      Research Center on Aging at Tufts University, Boston, USA, 723179127@qq.com.
FAU - Qin, Tingyu
AU  - Qin T
FAU - Zhou, Jilin
AU  - Zhou J
FAU - Taylor, Allen
AU  - Taylor A
FAU - Sparrow, Janet R
AU  - Sparrow JR
FAU - Shang, Fu
AU  - Shang F
LA  - eng
GR  - R01 EY012951/EY/NEI NIH HHS/United States
GR  - R01 EY011717/EY/NEI NIH HHS/United States
GR  - EY011717/EY/NEI NIH HHS/United States
GR  - P30 EY019007/EY/NEI NIH HHS/United States
GR  - R29 EY011717/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (CCL2 protein, human)
RN  - 0 (CXCL8 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (Ubiquitin)
RN  - 80295-65-4 (Complement Factor H)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
SB  - IM
MH  - Cell Line
MH  - Chemokine CCL2/immunology/metabolism
MH  - Complement Factor H/immunology/metabolism
MH  - Humans
MH  - Interleukin-6/immunology/metabolism
MH  - Interleukin-8/immunology/metabolism
MH  - *Macular Degeneration/immunology/metabolism/pathology
MH  - Oxidative Stress/immunology
MH  - Proteasome Endopeptidase Complex/*metabolism
MH  - Retinal Pigment Epithelium/cytology/*immunology/*metabolism
MH  - Retinitis/immunology/metabolism/pathology
MH  - Ubiquitin/*metabolism
PMC - PMC4828937
MID - NIHMS766870
EDAT- 2014/03/26 06:00
MHDA- 2014/07/25 06:00
PMCR- 2016/04/12
CRDT- 2014/03/26 06:00
PHST- 2014/03/26 06:00 [entrez]
PHST- 2014/03/26 06:00 [pubmed]
PHST- 2014/07/25 06:00 [medline]
PHST- 2016/04/12 00:00 [pmc-release]
AID - 10.1007/978-1-4614-3209-8_31 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2014;801:237-50. doi: 10.1007/978-1-4614-3209-8_31.