PMID- 24665163
OWN - NLM
STAT- MEDLINE
DCOM- 20141215
LR  - 20211021
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2014
DP  - 2014
TI  - Effect of the administration of alpha-lipoic acid on contrast sensitivity in 
      patients with type 1 and type 2 diabetes.
PG  - 131538
LID - 10.1155/2014/131538 [doi]
LID - 131538
AB  - The aim of this study was to estimate the effects of oral supplementation of 
      alpha-lipoic acid (ALA) on contrast sensitivity (CS) in patients with type 1 
      diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). The study included 
      12 patients with T1DM aged 43+/-12 years, 48 patients with T2DM aged 59+/-10 years, 
      and 20 control subjects aged 33+/-8 years. Patients from each studied group, 
      including the control group, were randomly assigned to receive 300 mg of ALA 
      orally once daily for 3 months. CS was evaluated with the Functional Acuity 
      Contrast Test (FACT, Stereo Optical). In the group of patients with T1DM 
      receiving ALA for 3 months CS remained stable and improved in those with T2DM. 
      Reduction of CS in both T1DM and T2DM patients without alpha-lipoic acid 
      supplementation was observed. In the control group on alpha-lipoic acid 
      supplementation, CS improvement was noticed at one spatial frequency. Changes in 
      the CS were observed, despite stable visual acuity and eye fundus image in all 
      studied subjects. Our study demonstrated that oral administration of alpha-lipoic 
      acid had influence on CS in both T1DM and T2DM patients.
FAU - Gebka, Anna
AU  - Gebka A
AD  - Department of Ophthalmology, Medical University of Gdansk, Smoluchowskiego 17, 
      80-214 Gdansk, Poland.
FAU - Serkies-Minuth, Ewelina
AU  - Serkies-Minuth E
AUID- ORCID: 0000-0002-5928-7056
AD  - Department of Ophthalmology, Medical University of Gdansk, Smoluchowskiego 17, 
      80-214 Gdansk, Poland.
FAU - Raczynska, Dorota
AU  - Raczynska D
AD  - Department of Ophthalmology, Medical University of Gdansk, Smoluchowskiego 17, 
      80-214 Gdansk, Poland ; Department of Anesthesiology and Intensive Care Medicine, 
      Medical University of Gdansk, Smoluchowskiego 17, 80-214 Gdansk, Poland.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20140210
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Antioxidants)
RN  - 73Y7P0K73Y (Thioctic Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antioxidants/administration & dosage
MH  - Case-Control Studies
MH  - Contrast Sensitivity/*drug effects
MH  - Diabetes Mellitus, Type 1/*physiopathology
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Diagnostic Techniques, Ophthalmological
MH  - Dietary Supplements
MH  - Female
MH  - Fundus Oculi
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Thioctic Acid/*administration & dosage
MH  - Visual Acuity
PMC - PMC3934387
EDAT- 2014/03/26 06:00
MHDA- 2014/12/17 06:00
PMCR- 2014/02/10
CRDT- 2014/03/26 06:00
PHST- 2013/08/16 00:00 [received]
PHST- 2013/11/28 00:00 [revised]
PHST- 2013/12/24 00:00 [accepted]
PHST- 2014/03/26 06:00 [entrez]
PHST- 2014/03/26 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
PHST- 2014/02/10 00:00 [pmc-release]
AID - 10.1155/2014/131538 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2014;2014:131538. doi: 10.1155/2014/131538. Epub 2014 Feb 10.