PMID- 24666112
OWN - NLM
STAT- MEDLINE
DCOM- 20141201
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 83
IP  - 5
DP  - 2014 May
TI  - Evaluation of HLA-DRB1 imputation using a Finnish dataset.
PG  - 350-5
LID - 10.1111/tan.12343 [doi]
AB  - Owing to the vast amount of alleles, high-resolution human leukocyte antigen 
      (HLA) typing is expensive and time-consuming. Scientists have attempted to 
      develop computational approaches to define HLA alleles with high confidence. We 
      tested the reliability of HLA*IMP and SNP2HLA for imputing HLA-DRB1 alleles in a 
      Finnish material (n=161). The per-individual success rates varied between 16.68% 
      and 25.4% using both softwares. One of the most prominent example was 
      HLA-DRB1*01:01 allele showing approximately a 30% success rate while being the 
      most common wrongly imputed allele. In Finland, isolation and migration history 
      have shaped the gene pool narrower showing HLA haplotype frequencies typical to 
      the Finnish population when compared to Europeans. The imputation success for 
      HLA-DRB1 alleles was very low pointing to the importance of population-specific 
      reference material.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Vlachopoulou, E
AU  - Vlachopoulou E
AD  - Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, 
      FI-00014, Finland.
FAU - Lahtela, E
AU  - Lahtela E
FAU - Wennerstrom, A
AU  - Wennerstrom A
FAU - Havulinna, A S
AU  - Havulinna AS
FAU - Salo, P
AU  - Salo P
FAU - Perola, M
AU  - Perola M
FAU - Salomaa, V
AU  - Salomaa V
FAU - Nieminen, M S
AU  - Nieminen MS
FAU - Sinisalo, J
AU  - Sinisalo J
FAU - Lokki, M-L
AU  - Lokki ML
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140326
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - *Alleles
MH  - Finland
MH  - Gene Frequency
MH  - Genetics, Population
MH  - HLA-DRB1 Chains/classification/*genetics/immunology
MH  - Haplotypes
MH  - Humans
MH  - *Software
MH  - White People/*genetics
OTO - NOTNLM
OT  - Finland
OT  - HLA imputation
OT  - HLA typing
OT  - HLA*IMP
OT  - HLA-DRB1
OT  - SNP2HLA
EDAT- 2014/03/29 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/03/27 06:00
PHST- 2013/11/01 00:00 [received]
PHST- 2014/02/11 00:00 [revised]
PHST- 2014/02/25 00:00 [accepted]
PHST- 2014/03/27 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1111/tan.12343 [doi]
PST - ppublish
SO  - Tissue Antigens. 2014 May;83(5):350-5. doi: 10.1111/tan.12343. Epub 2014 Mar 26.