PMID- 24666129
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20220309
IS  - 1530-8898 (Electronic)
IS  - 0898-929X (Linking)
VI  - 26
IP  - 9
DP  - 2014 Sep
TI  - Functional specialization within macaque dorsolateral prefrontal cortex for the 
      maintenance of task rules and cognitive control.
PG  - 1918-27
LID - 10.1162/jocn_a_00608 [doi]
AB  - The abilities of switching between and maintaining task rules are fundamental 
      aspects of goal-oriented behavior. The PFC is thought to implement the cognitive 
      processes underling such rule-based behavior, but the specific contributions of 
      the several cytoarchitecturally distinct subfields of PFC remain poorly 
      understood. Here, we used bilateral cryogenic deactivation to investigate the 
      relative contributions of two regions of the dorsolateral PFC (dlPFC)--the 
      inferior dlPFC (idlPFC) area, consisting of the cortex lining the caudal 
      principal sulcus, and the dorsally adjacent superior dlPFC (sdlPFC)--to different 
      aspects of rule-based behavior. Macaque monkeys performed two variants of a task 
      that required them to alternate unpredictably between eye movements toward 
      (prosaccade) or away from (antisaccade) a visual stimulus. In one version of the 
      task, the current rule was overtly cued. In the second, the task rule was uncued, 
      and successful performance required the animals to detect rule changes on the 
      basis of reward outcome and subsequently maintain the current task rule within 
      working memory. Deactivation of the idlPFC impaired the monkeys' ability to 
      perform pro- and antisaccades in the uncued task only. In contrast, deactivation 
      of the sdlPFC had no effect on performance in either task. Combined deactivation 
      of idlPFC and sdlPFC impaired performance on antisaccade, but not prosaccade, 
      trials in both task variants. These results suggest that the idlPFC is required 
      for mnemonic processes involved in maintenance of task rules, whereas both idlPFC 
      and sdlPFC together are necessary for the deployment of the cognitive control 
      required to perform antisaccades. Together, these data support the concept of a 
      functional specialization of subregions within the dlPFC for rule-guided 
      behavior.
FAU - Hussein, Sabeeha
AU  - Hussein S
AD  - University of Western Ontario.
FAU - Johnston, Kevin
AU  - Johnston K
FAU - Belbeck, Brandon
AU  - Belbeck B
FAU - Lomber, Stephen G
AU  - Lomber SG
FAU - Everling, Stefan
AU  - Everling S
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140325
PL  - United States
TA  - J Cogn Neurosci
JT  - Journal of cognitive neuroscience
JID - 8910747
RN  - Y4S76JWI15 (Methanol)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Attention/*physiology
MH  - Cognition/*physiology
MH  - Cues
MH  - Eye Movements/*physiology
MH  - Functional Laterality/physiology
MH  - *Goals
MH  - Macaca mulatta
MH  - Male
MH  - Memory, Short-Term/physiology
MH  - Methanol/pharmacology
MH  - Photic Stimulation
MH  - Prefrontal Cortex/drug effects/*physiology
MH  - Reaction Time/physiology
EDAT- 2014/03/29 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/03/27 06:00
PHST- 2014/03/27 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - 10.1162/jocn_a_00608 [doi]
PST - ppublish
SO  - J Cogn Neurosci. 2014 Sep;26(9):1918-27. doi: 10.1162/jocn_a_00608. Epub 2014 Mar 
      25.