PMID- 24667364
OWN - NLM
STAT- MEDLINE
DCOM- 20141211
LR  - 20220321
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 267
DP  - 2014 Jul 1
TI  - Luteolin protects against high fat diet-induced cognitive deficits in obesity 
      mice.
PG  - 178-88
LID - S0166-4328(14)00125-9 [pii]
LID - 10.1016/j.bbr.2014.02.040 [doi]
AB  - The epidemic and experimental studies have confirmed that the obesity can lead to 
      neuroinflammation, neurodegenerative diseases and adversely affect cognition. 
      Despite the numerous elucidations on the impact of obesity on cognition decline, 
      the contributors to the impairments in obesity remain unclear. Male C57BL/6J mice 
      were fed either a control or high-fat diet (HFD) for 16 weeks and then randomized 
      into four groups treated with their respective diets for 4 weeks including 
      control diet (CD); control diet+luteolin (CDL); high-fat diet (HFD), high-fat 
      diet+luteolin (HFDL). The dose of luteolin was 10mg/kg, oral. We showed that 
      adding luteolin in high-fat diet can significantly reduce body weight gain, food 
      intake and plasma cytokines as well as improving glucose metabolism of mice on 
      HFD. Importantly, we showed that luteolin treatment had the effects of 
      alleviating neuroinflammation, oxidative stress and neuronal insulin resistance 
      in the mouse brain, restored blood adipocytokines level to normal. Furthermore, 
      luteolin increased the level of brain-derived neurotrophic factor (BDNF), the 
      action of synapsin I (SYP) and postsynaptic density protein 95 (PSD-95) in the 
      cortex and hippocampus as to that the behavioral performance in Morris water maze 
      (MWM) and step-through task were significantly improved. These results indicate a 
      previously unrecognized potential of luteolin in alleviating obesity-induced 
      cognitive impairment for type-2 diabetes mellitus and Alzheimer disease (AD).
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Liu, Yi
AU  - Liu Y
AD  - Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, 
      Jiangsu Province, China. Electronic address: cbpe201087@gmail.com.
FAU - Fu, Xiaobin
AU  - Fu X
AD  - Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, 
      Jiangsu Province, China. Electronic address: cbpe201104@163.com.
FAU - Lan, Nuo
AU  - Lan N
AD  - Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, 
      Jiangsu Province, China. Electronic address: xinjingwutong@163.com.
FAU - Li, Sai
AU  - Li S
AD  - Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, 
      Jiangsu Province, China. Electronic address: lisai0821@sina.com.
FAU - Zhang, Jingzheng
AU  - Zhang J
AD  - Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, 
      Jiangsu Province, China. Electronic address: zjingzlove@163.com.
FAU - Wang, Shuaishuai
AU  - Wang S
AD  - Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, 
      Jiangsu Province, China. Electronic address: wszc0220@126.com.
FAU - Li, Cheng
AU  - Li C
AD  - Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, 
      Jiangsu Province, China. Electronic address: lc510520@126.com.
FAU - Shang, Yanguo
AU  - Shang Y
AD  - Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, 
      Jiangsu Province, China. Electronic address: dashanlidenanhaiwo@163.com.
FAU - Huang, Tonghui
AU  - Huang T
AD  - Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, 
      Jiangsu Province, China. Electronic address: tonghhuang@gmail.com.
FAU - Zhang, Ling
AU  - Zhang L
AD  - Department of Pharmacy, School of Pharmacy, Xuzhou Medical College, Xuzhou, 
      Jiangsu Province, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140322
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Adipokines)
RN  - 0 (Anti-Obesity Agents)
RN  - 0 (Blood Glucose)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 0 (Disks Large Homolog 4 Protein)
RN  - 0 (Dlg4 protein, mouse)
RN  - 0 (Membrane Proteins)
RN  - 0 (Synapsins)
RN  - EC 2.7.4.8 (Guanylate Kinases)
RN  - KUX1ZNC9J2 (Luteolin)
SB  - IM
MH  - Adipokines/blood
MH  - Animals
MH  - Anti-Obesity Agents/*pharmacology
MH  - Blood Glucose/metabolism
MH  - Brain/*drug effects/pathology/physiopathology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cognition Disorders/etiology/pathology/physiopathology/*prevention & control
MH  - Cytokines/blood
MH  - Diet, High-Fat/*adverse effects
MH  - Disks Large Homolog 4 Protein
MH  - Eating/drug effects
MH  - Guanylate Kinases/metabolism
MH  - Insulin Resistance/physiology
MH  - Luteolin/*pharmacokinetics
MH  - Male
MH  - Maze Learning/drug effects/physiology
MH  - Membrane Proteins/metabolism
MH  - Mice, Inbred C57BL
MH  - Neuroimmunomodulation/drug effects/physiology
MH  - Neurons/drug effects/pathology/physiology
MH  - Obesity/complications/*drug therapy/pathology/physiopathology
MH  - Oxidative Stress/drug effects/physiology
MH  - Synapsins/metabolism
MH  - Weight Gain/drug effects
OTO - NOTNLM
OT  - C57BL/6J mice
OT  - High-fat diet
OT  - Luteolin
OT  - Neuronal insulin resistance
OT  - Obesity
OT  - Synaptic plasticity
EDAT- 2014/03/29 06:00
MHDA- 2014/12/17 06:00
CRDT- 2014/03/27 06:00
PHST- 2013/12/03 00:00 [received]
PHST- 2014/02/21 00:00 [revised]
PHST- 2014/02/26 00:00 [accepted]
PHST- 2014/03/27 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
AID - S0166-4328(14)00125-9 [pii]
AID - 10.1016/j.bbr.2014.02.040 [doi]
PST - ppublish
SO  - Behav Brain Res. 2014 Jul 1;267:178-88. doi: 10.1016/j.bbr.2014.02.040. Epub 2014 
      Mar 22.