PMID- 24667541
OWN - NLM
STAT- MEDLINE
DCOM- 20150122
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 3
DP  - 2014
TI  - Platelet serotonin transporter function predicts default-mode network activity.
PG  - e92543
LID - 10.1371/journal.pone.0092543 [doi]
LID - e92543
AB  - BACKGROUND: The serotonin transporter (5-HTT) is abundantly expressed in humans 
      by the serotonin transporter gene SLC6A4 and removes serotonin (5-HT) from 
      extracellular space. A blood-brain relationship between platelet and synaptosomal 
      5-HT reuptake has been suggested, but it is unknown today, if platelet 5-HT 
      uptake can predict neural activation of human brain networks that are known to be 
      under serotonergic influence. METHODS: A functional magnetic resonance study was 
      performed in 48 healthy subjects and maximal 5-HT uptake velocity (Vmax) was 
      assessed in blood platelets. We used a mixed-effects multilevel analysis 
      technique (MEMA) to test for linear relationships between whole-brain, 
      blood-oxygen-level dependent (BOLD) activity and platelet Vmax. RESULTS: The 
      present study demonstrates that increases in platelet Vmax significantly predict 
      default-mode network (DMN) suppression in healthy subjects independent of genetic 
      variation within SLC6A4. Furthermore, functional connectivity analyses indicate 
      that platelet Vmax is related to global DMN activation and not intrinsic DMN 
      connectivity. CONCLUSION: This study provides evidence that platelet Vmax 
      predicts global DMN activation changes in healthy subjects. Given previous 
      reports on platelet-synaptosomal Vmax coupling, results further suggest an 
      important role of neuronal 5-HT reuptake in DMN regulation.
FAU - Scharinger, Christian
AU  - Scharinger C
AD  - Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, 
      Austria.
FAU - Rabl, Ulrich
AU  - Rabl U
AD  - Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, 
      Austria.
FAU - Kasess, Christian H
AU  - Kasess CH
AD  - Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, 
      Austria; Center for Medical Physics and Biomedical Engineering, Medical 
      University of Vienna, Vienna, Austria.
FAU - Meyer, Bernhard M
AU  - Meyer BM
AD  - Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, 
      Austria.
FAU - Hofmaier, Tina
AU  - Hofmaier T
AD  - Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria; 
      Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, 
      Vienna, Austria.
FAU - Diers, Kersten
AU  - Diers K
AD  - Department of Psychology, Dresden University of Technology, Dresden, Germany.
FAU - Bartova, Lucie
AU  - Bartova L
AD  - Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, 
      Austria.
FAU - Pail, Gerald
AU  - Pail G
AD  - Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, 
      Austria.
FAU - Huf, Wolfgang
AU  - Huf W
AD  - Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, 
      Austria; Center for Medical Physics and Biomedical Engineering, Medical 
      University of Vienna, Vienna, Austria; Department of Statistics and Probability 
      Theory, Vienna University of Technology, Vienna, Austria.
FAU - Uzelac, Zeljko
AU  - Uzelac Z
AD  - Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, 
      Vienna, Austria.
FAU - Hartinger, Beate
AU  - Hartinger B
AD  - Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, 
      Austria.
FAU - Kalcher, Klaudius
AU  - Kalcher K
AD  - Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, 
      Austria; Center for Medical Physics and Biomedical Engineering, Medical 
      University of Vienna, Vienna, Austria; Department of Statistics and Probability 
      Theory, Vienna University of Technology, Vienna, Austria.
FAU - Perkmann, Thomas
AU  - Perkmann T
AD  - Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
FAU - Haslacher, Helmuth
AU  - Haslacher H
AD  - Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
FAU - Meyer-Lindenberg, Andreas
AU  - Meyer-Lindenberg A
AD  - Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
FAU - Kasper, Siegfried
AU  - Kasper S
AD  - Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, 
      Austria.
FAU - Freissmuth, Michael
AU  - Freissmuth M
AD  - Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, 
      Vienna, Austria.
FAU - Windischberger, Christian
AU  - Windischberger C
AD  - Center for Medical Physics and Biomedical Engineering, Medical University of 
      Vienna, Vienna, Austria.
FAU - Willeit, Matthaus
AU  - Willeit M
AD  - Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, 
      Austria.
FAU - Lanzenberger, Rupert
AU  - Lanzenberger R
AD  - Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, 
      Austria.
FAU - Esterbauer, Harald
AU  - Esterbauer H
AD  - Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
FAU - Brocke, Burkhard
AU  - Brocke B
AD  - Department of Psychology, Dresden University of Technology, Dresden, Germany.
FAU - Moser, Ewald
AU  - Moser E
AD  - Center for Medical Physics and Biomedical Engineering, Medical University of 
      Vienna, Vienna, Austria.
FAU - Sitte, Harald H
AU  - Sitte HH
AD  - Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, 
      Vienna, Austria.
FAU - Pezawas, Lukas
AU  - Pezawas L
AD  - Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, 
      Austria.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140325
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (SLC6A4 protein, human)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Platelets/*physiology
MH  - Brain/*physiology
MH  - *Connectome
MH  - Female
MH  - Functional Neuroimaging
MH  - Genetic Variation
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Neural Pathways
MH  - Serotonin/*metabolism
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics
MH  - Young Adult
PMC - PMC3965432
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2014/03/29 06:00
MHDA- 2015/01/23 06:00
PMCR- 2014/03/25
CRDT- 2014/03/27 06:00
PHST- 2012/12/27 00:00 [received]
PHST- 2014/02/25 00:00 [accepted]
PHST- 2014/03/27 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2015/01/23 06:00 [medline]
PHST- 2014/03/25 00:00 [pmc-release]
AID - PONE-D-13-00722 [pii]
AID - 10.1371/journal.pone.0092543 [doi]
PST - epublish
SO  - PLoS One. 2014 Mar 25;9(3):e92543. doi: 10.1371/journal.pone.0092543. eCollection 
      2014.