PMID- 24667697
OWN - NLM
STAT- MEDLINE
DCOM- 20150115
LR  - 20151119
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 433
DP  - 2014 Jun 10
TI  - The cytokeratin-18 fragment level as a biomarker of nonalcoholic fatty liver 
      disease in patients with type 2 diabetes mellitus.
PG  - 184-9
LID - S0009-8981(14)00126-0 [pii]
LID - 10.1016/j.cca.2014.03.018 [doi]
AB  - BACKGROUND: The serum cytokeratin-18 fragment (CK-18) concentration has been 
      suggested to be a biomarker of nonalcoholic fatty liver disease (NAFLD), although 
      its usefulness in patients with type 2 diabetes mellitus (T2DM) is unknown. 
      METHODS: The study was divided into two parts. In the first cross-sectional 
      study, a total of 200 patients with T2DM and 58 healthy control subjects were 
      recruited. NAFLD was diagnosed using ultrasonography. In the subsequent 
      longitudinal study, we evaluated the three-month change (Delta) in the CK-18 
      concentration and other parameters in 40 T2DM patients with NAFLD. RESULTS: The 
      serum CK-18 values were significantly higher in the NAFLD group than in the 
      nonNAFLD group among both diabetic and nondiabetic subjects. The CK-18 
      concentration was found to be an independent determinant of NAFLD and was 
      positively correlated with the ultrasonography score and AST and ALT 
      concentrations in the T2DM patients. Positive correlations were also identified 
      between the CK-18 and transaminase concentrations in the T2DM and NAFLD cohorts. 
      DeltaCK-18 was found to be significantly associated with DeltaBMI in the T2DM patients 
      with NAFLD. CONCLUSIONS: A dose effect between the CK-18 concentration and the 
      severity of NAFLD was found in the T2DM patients; thus, the CK-18 concentration 
      is a potentially useful biomarker for assessing the efficacy of treatment and the 
      improvement in NAFLD in patients with T2DM.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Miyasato, Mai
AU  - Miyasato M
AD  - Department of Internal Medicine (I), Osaka Medical College, Osaka, Japan.
FAU - Murase-Mishiba, Yuko
AU  - Murase-Mishiba Y
AD  - Department of Internal Medicine (I), Osaka Medical College, Osaka, Japan. 
      Electronic address: in1254@poh.osaka-med.ac.jp.
FAU - Bessho, Megumi
AU  - Bessho M
AD  - Department of Internal Medicine (I), Osaka Medical College, Osaka, Japan.
FAU - Miyawaki, Masahiro
AU  - Miyawaki M
AD  - Department of Internal Medicine (I), Osaka Medical College, Osaka, Japan.
FAU - Imbe, Hisashi
AU  - Imbe H
AD  - Department of Internal Medicine (I), Osaka Medical College, Osaka, Japan.
FAU - Tsutsumi, Chiharu
AU  - Tsutsumi C
AD  - Department of Internal Medicine (I), Osaka Medical College, Osaka, Japan.
FAU - Tanimoto, Keiji
AU  - Tanimoto K
AD  - Department of Internal Medicine (I), Osaka Medical College, Osaka, Japan.
FAU - Imagawa, Akihisa
AU  - Imagawa A
AD  - Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 
      Osaka, Japan.
FAU - Terasaki, Jungo
AU  - Terasaki J
AD  - Department of Internal Medicine (I), Osaka Medical College, Osaka, Japan.
FAU - Hanafusa, Toshiaki
AU  - Hanafusa T
AD  - Department of Internal Medicine (I), Osaka Medical College, Osaka, Japan.
LA  - eng
PT  - Journal Article
DEP - 20140322
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Biomarkers)
RN  - 0 (Keratin-18)
RN  - 0 (Peptide Fragments)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Humans
MH  - Keratin-18/blood/*chemistry
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease/*blood/*complications
MH  - Peptide Fragments/*blood
OTO - NOTNLM
OT  - Apoptosis
OT  - Noninvasive biomarker
OT  - Ultrasonography scoring system
EDAT- 2014/03/29 06:00
MHDA- 2015/01/16 06:00
CRDT- 2014/03/27 06:00
PHST- 2013/10/04 00:00 [received]
PHST- 2014/03/07 00:00 [revised]
PHST- 2014/03/17 00:00 [accepted]
PHST- 2014/03/27 06:00 [entrez]
PHST- 2014/03/29 06:00 [pubmed]
PHST- 2015/01/16 06:00 [medline]
AID - S0009-8981(14)00126-0 [pii]
AID - 10.1016/j.cca.2014.03.018 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2014 Jun 10;433:184-9. doi: 10.1016/j.cca.2014.03.018. Epub 2014 
      Mar 22.